This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $4,041,438 to develop new computational tools and biomarkers for Alzheimer's disease. The University of Miami will aggregate and analyze DNA methylation datasets to identify age-associated epigenetic changes related to aging and Alzheimer's progression. Researchers will create a searchable web interface to disseminate findings on the role of DNA...
The National Institute on Aging (NIA) awarded a $2,288,327 Project Grant (CFDA 93.866 - Aging Research) to the University of California, San Diego (UCSD) on August 15, 2024. The grant funding will support research to investigate the early determinants and pathogenesis of Alzheimer's disease (AD) using age-equivalent neurons derived from mild cognitive impairment (MCI) patient samples. The research teams will utilize patient-derived induced neurons to study how polygenic risk factors and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $146,922.00 to The Trustees of Columbia University in the City of New York to conduct research on the impact of Alzheimer's disease on genetic signatures of hippocampal memory traces. The research project will use cutting-edge techniques like single-nuclear RNA sequencing to compare the gene expression profiles of engram cells (cells that store memories) in normal mice versus a mouse model of...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,241,676 to The University of Iowa to investigate the role of glycolysis, a key glucose metabolism process, in rodent models of Alzheimer's disease. The project aims to interrogate how disruptions in glycolysis affect neurodegeneration in Alzheimer's disease models, and whether enhancing glycolysis can mitigate neurodegeneration. The research will utilize advanced imaging techniques,...
This $2,119,771 Project Grant award from the National Institute on Aging (under CFDA 93.866 - Aging Research) will fund research at the University of Massachusetts Medical School (UMass Medical) to investigate the role of peripheral insulin resistance and inflammation in Alzheimer's disease (AD) pathogenesis. The project aims to define age-related changes in metabolism and inflammation in peripheral organs, particularly the liver, and examine how these processes impact AD-relevant...
This National Institute on Aging R01 Project Grant Award (CFDA 93.866 - Aging Research) provides $745,092 to the University of Virginia to conduct research on the epitranscriptomic mechanisms underlying the pathogenesis of Alzheimer's disease (AD) and related tauopathies. The key objectives are to: 1) Decode the epitranscriptomic profiles impacted by tau pathology using m6A DART-seq, 2) Determine the role of RNA methylation in AD pathogenesis using 3D neuron-glial brain assembloids, and 3)...
The National Institute on Aging (NIA) awarded a $429,000 Project Grant (CFDA 93.866 - Aging Research) to Northeast Ohio Medical University (Neomed) to evaluate the role of acetylation on brain proteome dynamics in a mouse model of Alzheimer's Disease (AD) and type 2 diabetes mellitus (T2DM). The 2-year project aims to quantify proteome and acetylome dynamics in the hippocampus and frontal cortex of diet-induced diabetic and non-diabetic AD mice to determine the effect of T2DM-related...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of California, Los Angeles (UCLA) provides $258,498 to conduct research investigating the biological pathways linking sleep health, Alzheimer's disease, and cognitive decline. The 5-year project has three main aims: Utilize a multi-omics approach to analyze methylation and metabolomics data associated with short sleep and insomnia among a high-risk Hispanic population, and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $446,875 to The Trustees of the University of Pennsylvania to conduct research into the potential pleotropic effects of genetic risk variants for Alzheimer's disease on sleep. The study aims to assess whether genetic variants associated with Alzheimer's disease risk also impact sleep duration and other sleep phenotypes, using a combination of bioinformatic analysis and in vivo studies in...
This federal Project Grant award, funded by the National Institute on Aging (CFDA 93.866 - Aging Research), provides $6,226,692 to The Trustees of Columbia University in the City of New York to conduct research on the role of neuronal hyperexcitability and proteostasis (protein homeostasis) in the progression of Alzheimer's disease. The research aims to identify key early events in Alzheimer's disease pathology, particularly in the locus coeruleus and hippocampus regions of the brain, and...
The National Institute on Aging (NIA) awarded a $419,005 Project Grant under the Aging Research program (CFDA 93.866) to Purdue University on May 15, 2025. The grant will support research to investigate how Alzheimer's disease alters one-carbon metabolism and histone methylation, and how these changes may disrupt circadian rhythms and sleep patterns. The project will leverage the Drosophila (fruit fly) model system to identify conserved mechanisms underlying the link between Alzheimer's-associated metabolic and epigenetic changes, and disruptions in circadian behaviors observed in both aging and Alzheimer's disease. Key research activities will focus on the roles of the enzymes GNMT, NNMT, and AHCY in modulating the SAM:SAH ratio and impacting circadian gene expression. These studies aim to provide a foundation for expanding the university's work on metabolism, epigenetics, and circadian regulation from the aging eye into the context of neurodegenerative disease, with a particular emphasis on Alzheimer's disease.