The National Institutes of Health's National Institute on Aging awarded a $2,366,184 Project Grant to The General Hospital Corporation, doing business as Massachusetts General Hospital, to support research into the mechanisms of circadian and synaptic dysfunction after repetitive mild traumatic brain injury. The three-year award, made on June 1, 2022 under the Aging Research program (CFDA 93.866), will fund work by Drs. Whalen and Lipton to define how interleukin-1 receptor 1-mediated phosphorylation of BMAL1 signaling in response to mild TBI corrupts the timing of synaptic function and impairs plasticity. A subaward of $500,000 to The Children's Hospital Corporation, doing business as Boston Children's Hospital, will support Dr. Lipton's experiments there on circadian biology, synaptic biology, ultrastructural analyses, and cellular signaling in mouse models. The research aims to provide new insights into mild TBI-induced cognitive dysfunction and identify therapeutic targets to alleviate concussion sequelae, advancing the goals of the Aging Research program.