The U.S. National Heart, Lung, and Blood Institute (NHLBI) awarded a $655,655 Project Grant under CFDA 93.837 Cardiovascular Diseases Research to Northwestern University to investigate the physiological and behavioral basis of Delayed Sleep-Wake Phase Disorder (DSWPD). The research project aims to identify distinct DSWPD subtypes based on differences in circadian timing and light sensitivity, and use these findings to inform the development of personalized treatment approaches. The study will enroll 220 DSWPD patients and conduct comprehensive circadian, behavioral, and mood assessments using actigraphy, melatonin sampling, pupillometry, and questionnaires. The data will be integrated through mathematical modeling to characterize DSWPD phenotypes. Outcomes from this grant-funded research are expected to advance the understanding of DSWPD pathophysiology and guide the implementation of targeted, mechanism-based interventions for circadian rhythm disorders.
Generated 2/25/25, 3:23 AM