Project Grant HT94252510645

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, is providing $426,938 to Virginia Commonwealth University to explore the role of a novel glutamate-driven signaling pathway initiated in maturing oligodendrocytes through the glutamate transporter GLT-1/EAAT2. This research aims to characterize the mechanisms downstream of...

This $440,275 Project Grant, awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to systematically discover upstream regulators of the OLIG2 transcription factor, which plays a central role in oligodendrocyte lineage specification and central nervous system myelination. The award was granted to The Research Foundation For The State...

This federal Project Grant award of $614,009, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research aimed at understanding the molecular mechanisms of oligodendrocyte myelination and remyelination. The research, conducted by the Children's Hospital Medical Center in Cincinnati, Ohio, focuses on identifying critical factors that promote myelin...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $235,500.00 to Rutgers, The State University to conduct research on the role of the choline transporter CTL1 in oligodendrocyte function and myelin formation. The goal is to elucidate the mechanism by which oligodendrocytes acquire choline, an essential nutrient for myelin lipid...

This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the role of membrane-remodeling factors in regulating oligodendrocyte morphology and central nervous system (CNS) myelination. The $458,189 award to the University of Texas Medical Branch at Galveston will fund a 5-year project to (1) identify...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $439,027 to The Johns Hopkins University to conduct research on the role of a gut microbiota metabolite, indole lactate (ILA), in promoting myelin repair for the treatment of multiple sclerosis (MS). The research aims to demonstrate ILA's ability to overcome barriers to remyelination in MS...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $506,083.00 to Artificial Axon Labs Inc. to develop a novel biomimetic 3D-printed drug discovery platform called "Artificial Axons" for screening remyelinating compounds to treat multiple sclerosis (MS) and other myelin diseases. The key products and services...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $426,057 in funding to Duquesne University to evaluate the response of oligodendrocyte precursor cells (OPCs) during a viral infection in the developing brain. The project aims to define the protective role of juvenile immune cells in promoting OPC proliferation and the...

This three-year, $3.24 million project grant from the National Institutes of Health National Institute on Aging will fund research into the role of clusterin in oligodendrocyte lineage and myelination in Alzheimer's disease. Specifically, the University of Virginia researchers will pursue three aims: 1) determine the mechanisms of clusterin expression and its inhibition of oligodendrocyte progenitor cell differentiation; 2) assess the impact of pathological clusterin expression on myelination,...

This federal Project Grant award, valued at $599,204.00 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the cellular mechanisms that drive learning-induced myelin remodeling and its role in motor learning. The key objectives are to: (1) determine whether calcium signaling is required for myelin sheath shortening...