Project Grant HT94252510430

This federal Project Grant award, valued at $599,204.00 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the cellular mechanisms that drive learning-induced myelin remodeling and its role in motor learning. The key objectives are to: (1) determine whether calcium signaling is required for myelin sheath shortening...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $551,250 to the University of California, Los Angeles (UCLA) to conduct research on the molecular mechanisms underlying the formation of synaptic connections between neurons in the brain. The key objectives of this 1-year award, which runs from June 1, 2025 to May 31, 2026, are...

This $1,361,648 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support a multi-scale, multi-modal longitudinal imaging study to examine the association of cognitive function with changes in brain structure, function, and neuronal integrity in patients with multiple sclerosis (MS). The primary research objectives are to: 1)...

The National Institute on Aging (NIA) awarded The Leland Stanford Junior University (Stanford University) a $428,563 Project Grant under the Aging Research Program (CFDA 93.866) to develop a modular cell-on-chip platform to study how neuronal activity regulates myelin sheath formation and how these dynamics are altered in neurodegenerative disease. The 2-year project will enable fine-tuning of neuronal stimulation, recording of extracellular activity, and high-resolution imaging of myelin...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, is providing $426,938 to Virginia Commonwealth University to explore the role of a novel glutamate-driven signaling pathway initiated in maturing oligodendrocytes through the glutamate transporter GLT-1/EAAT2. This research aims to characterize the mechanisms downstream of...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $654,287 to the Icahn School of Medicine at Mount Sinai to conduct a study on cognitive impairment in multiple sclerosis (MS). The goal is to develop a psychometrically valid and biologically informed model of cognitive status in relapsing-remitting and progressive MS by...

This $233,250 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund research at The Washington University to investigate the potential of hyperpolarized 13C magnetic resonance spectroscopic imaging (HP 13C MRSI) and ultra-short echo time magnetization transfer (UTE-MT) imaging to non-invasively study the role of lactate metabolism and...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $506,083.00 to Artificial Axon Labs Inc. to develop a novel biomimetic 3D-printed drug discovery platform called "Artificial Axons" for screening remyelinating compounds to treat multiple sclerosis (MS) and other myelin diseases. The key products and services...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $249,750 to the University of Connecticut Health Center to conduct research on the molecular mechanisms by which the synaptic protein C1QL3 promotes excitatory synapse formation and function. The key objectives are to elucidate the structural basis for C1QL3's transsynaptic...

This $251,370 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to understand the role of the transcription factor BMAL1 in regulating oligodendrocyte precursor cell (OPC) differentiation and myelination. The research aims to characterize BMAL1's impact on OPC transcriptional regulation, evaluate methods to restore OPC...