This federal Project Grant award of $551,250 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports research to uncover the molecular basis of synaptic specificity in the Drosophila visual system. The research focuses on how different synapses form in distinct dendritic domains and how neurons select between potential synaptic partners. Key activities include tagging specific synaptic proteins to determine their precise subcellular localization, identifying synapse-associated protein complexes using affinity purification-mass spectrometry, and exploring the role of cell recognition molecules and synaptic adhesion proteins in regulating synaptic specificity. The award, with a period of performance from June 1, 2025 to May 31, 2026, aims to provide fundamental insights into the molecular mechanisms governing the formation of neuronal connections, which is critical for understanding and potentially treating neurological and psychiatric disorders.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $551.3k | 5/30/25 |