This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $249,750.00 to the University of Connecticut Health Center to conduct research on the molecular mechanisms of the synaptic adhesion protein C1QL3 and its role in regulating excitatory synapse formation and function.
The key objectives of the research are to: 1) Elucidate the structural basis for C1QL3's interactions with the binding partners ADGRB3 and NPTX1/R, and characterize how these interactions promote synapse formation and maintenance; and 2) Determine the mechanism by which matrix metalloproteinases (MMPs) regulate the C1QL3-mediated synaptic adhesion complex and synaptic homeostasis. The award has a project period from April 1, 2025 to March 31, 2027.
Generated 3/25/25, 3:25 AM