Project Grant HT94252310773

Under this $575,000 Project Grant awarded September 1, 2025, by the National Science Foundation's Division of Chemistry (Mathematical and Physical Sciences program, CFDA 47.049), Professor Haimei Zheng at the University of California, Berkeley will conduct fundamental research on copper-based bimetallic nanocatalysts for electrochemical carbon dioxide reduction (CO2RR). The primary deliverable is the development and validation of in-situ operando electrochemical liquid cell transmission electron...

This $600,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program will support research at the University of Michigan and Trinity University to investigate the structural and electronic properties of high-valent cobalt, nickel, and copper-oxo complexes. The project aims to improve understanding of how metal-oxo versus metal-oxyl character impacts the stability and reactivity of these unstable, yet potentially useful,...

This Project Grant award, funded by the National Science Foundation (NSF) Division of Chemistry under the Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049), supports research at the University of Texas at Austin to study how the secondary coordination sphere (SCS) affects the activity of copper enzymes. The $594,870 award from August 1, 2024 to July 31, 2027 employs a novel biosynthetic approach to modulate copper enzyme activity, with potential applications in areas like...

The Department of Defense's Military Medical Research and Development program (CFDA 12.420) awarded a $796,875 project grant to the University of Florida (UF) Division of Sponsored Research. The grant, awarded on April 1, 2024, supports the development of heterobifunctional degraders of TDP-43 as a novel therapeutic strategy for amyotrophic lateral sclerosis (ALS). Under this grant, the University of North Carolina at Chapel Hill (UNC-CH) Office of Sponsored Research is serving as a sub-awardee....

This NSF-BSF Project Grant award, valued at $774,534, supports the development of experimental electron paramagnetic resonance (EPR) methodology and associated simulation techniques to elucidate the sensing and transcription mechanism of a copper-inducible repressor protein (CopY) found in pathogenic bacteria. The primary objectives are to: 1) Improve the sensitivity of pulsed EPR distance measurement methods and generate orthogonal labeling schemes based on a novel site-directed spin label; and...

The Defense Health Agency awarded a $458,516 Project Grant to Mayo Clinic Jacksonville to support research titled "NOVEL THERAPEUTICS TARGETING STRESS GRANULES FOR C9ORF72-MEDIATED ALS." The grant period runs from February 1, 2021 through June 30, 2022. The grant supports research into novel therapeutics targeting stress granules for the treatment of amyotrophic lateral sclerosis (ALS) caused by mutations in the C9orf72 gene. This work falls under the Military Medical Research and...

This $525,177 federal Project Grant award was provided by the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program to Professor Christian R. Goldsmith at Auburn University. The funding supports the development and mechanistic characterization of new coordination complexes that functionally mimic the antioxidant enzyme catalase. The proposed catalase mimics are manganese, iron, and zinc complexes with redox-active organic ligands, with the goal of...

This Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $2,181,250 in funding to the Seattle Institute For Biomedical And Clinical Research to develop small molecule inhibitors of the MSUT2 protein as a potential therapeutic approach for treating tauopathy disorders such as frontotemporal lobar degeneration, Alzheimer's disease, and related conditions. The project aims to optimize potent and brain-penetrant MSUT2 inhibitors and demonstrate...

This federal Project Grant award from the Department of Defense's Military Medical Research and Development program (CFDA 12.420) provides $1,008,091 to The Trustees of Columbia University in the City of New York, doing business as the Health Sciences Division, to develop a high-throughput and multiplex platform for engineering TCR-Tregs for ALS therapy. The award term runs from May 1, 2024 to April 30, 2026. Columbia University will work with a sub-grantee, Mayo Clinic Arizona, to generate...

The Trustees of Columbia University in New York City will receive $809,262 from the Department of the Army Medical Command under a Project Grant award to support preclinical characterization of AZVIII-7-18, a novel Paullone derivative for the treatment of ALS. The funding period is from July 1, 2022 to June 30, 2024. The award is being made through the Military Medical Research and Development program (CFDA 12.420), which supports basic, applied, and advanced biomedical research aimed at...