Project Grant RF1AG078335

Award Date 9/1/23
Completion Date 8/31/26
Dollars Obligated $2.2M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Seattle, WA 98108, USA
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Jillion Therapeutics Inc. aims to identify small molecule compounds that can bind to and modify the biological behavior of tau protein, which is implicated in Alzheimer's disease and other neurodegenerative "tauopathies". The $496,373 award, spanning September 2024 to August 2025, will utilize the company's DNA-encoded library (DEL) drug discovery platform to screen a large chemical...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) is providing $2,836,419 to the Seattle Institute for Biomedical and Clinical Research to investigate how the SUT-6/NIPP1 protein regulates pathological tau in Alzheimer's disease and other neurodegenerative "tauopathy" conditions. The key objectives are to: 1) define the functions of SUT-6/NIPP1 important for suppressing tau toxicity in a C. elegans model, 2) identify downstream...
This $519,750 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a 2-year research study by the J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco. The study aims to explore the underlying molecular mechanisms by which reducing levels of the tau protein can prevent or diminish excitation/inhibition imbalance and network hyperexcitability in the brain. This imbalance has been observed in various...
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The project aims to optimize potent and brain-penetrant MSUT2 inhibitors and demonstrate proof-of-concept efficacy in treating tau pathology. This involves synthesizing analogs, evaluating physicochemical properties, analyzing structure-activity relationships, and conducting in vitro and in vivo studies. The University of Pennsylvania and University of California, San Diego are serving as sub-awardees on this project to support hit/lead optimization efforts, compound synthesis, and pharmacokinetic/tolerability assessments. Successful completion of this project is expected to generate MSUT2-specific tool compounds and further validate this novel therapeutic target for tauopathy disorders.

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