This Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $2,181,250 in funding to the Seattle Institute For Biomedical And Clinical Research to develop small molecule inhibitors of the MSUT2 protein as a potential therapeutic approach for treating tauopathy disorders such as frontotemporal lobar degeneration, Alzheimer's disease, and related conditions. The project aims to optimize potent and brain-penetrant MSUT2 inhibitors and demonstrate proof-of-concept efficacy in treating tau pathology. This involves synthesizing analogs, evaluating physicochemical properties, analyzing structure-activity relationships, and conducting in vitro and in vivo studies. The University of Pennsylvania and University of California, San Diego are serving as sub-awardees on this project to support hit/lead optimization efforts, compound synthesis, and pharmacokinetic/tolerability assessments. Successful completion of this project is expected to generate MSUT2-specific tool compounds and further validate this novel therapeutic target for tauopathy disorders.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $2.2m | 8/16/23 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
KB29BUPENN2S | The Trustees Of The University Of Pennsylvania | Project Grant RF1AG078335 | $144.6k | 10/17/24 | |
KB29BUCSD2S | University Of California, San Diego | Project Grant RF1AG078335 | $298.8k | 9/10/24 | |
KB29BUPENN1S | The Trustees Of The University Of Pennsylvania | Project Grant RF1AG078335 | $141.6k | 10/27/23 | |
KB29BUCSD1S | University Of California, San Diego | Project Grant RF1AG078335 | $298.8k | 10/23/23 |