This National Science Foundation (NSF) Project Grant under the CFDA program "Biological Sciences" (47.074) is awarded to Trustees of Boston University to develop and optimize optogenetic tools for selecting bacterial cells based on dynamic, time-varying traits. The $796,158 award, effective August 1, 2023 through July 31, 2026, supports the researchers in creating light-inducible genetic constructs that trigger antibiotic resistance, enabling the isolation of bacteria exhibiting...
This federal Project Grant award for $350,487, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to expand research on high-valent bis-FeIV (iron) cofactors in microbial heme-containing metalloenzymes. The project seeks to uncover the fundamental mechanisms by which bacteria stabilize and utilize these reactive bis-FeIV species to facilitate site-specific substrate oxidation reactions. The...
The National Science Foundation Division of Molecular and Cellular Biosciences awarded a $1,050,082 Project Grant to the University of Pittsburgh to support research titled "The Virtues of Lanthanides and Fluorine for Tracking In-Cell Protein Conformation: A Marriage of NMR and EPR" from June 1, 2021 to May 31, 2025. This Project Grant funding will support research under the Biological Sciences federal grant program (CFDA 47.074) to advance understanding of major biological problems....
This $700,000 Project Grant award from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program supports research to examine how iron-starved bacteria cope with additional stresses, such as nitric oxide. The project investigates the underlying mechanisms that enable some bacterial species, like Escherichia coli, to adapt to these multi-stress conditions, while others, like Pseudomonas aeruginosa, cannot. The research aims to elucidate principles of adaptation for...
This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $373,168 supports collaborative research between the University of Wisconsin-Milwaukee and Northeastern Illinois University to understand the molecular mechanisms behind how myxobacteria use phytochromes to sense light and convert that signal into developmental changes, such as fruiting body formation. The research will utilize cutting-edge techniques including time-resolved X-ray...
The National Science Foundation (NSF) awarded a $626,831 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Wisconsin-Milwaukee (UWM) to conduct collaborative research on the molecular mechanisms behind how certain bacteria use light-sensing proteins called phytochromes to regulate essential developmental processes. The project aims to use advanced structural biology techniques like cryo-electron microscopy and time-resolved X-ray crystallography to study...
The National Science Foundation (NSF) awarded a $740,797 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to the Regents of the University of California, San Francisco (UCSF) to develop and test new methodologies for the rational design of minimalistic light-switchable single-domain proteins. The goal is to engineer these proteins to bind specifically to target proteins in only one photoswitchable chromophore state, allowing for precise spatial and temporal control...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $382,854 in funding to the University of Texas at Dallas (UTD) to investigate the biochemical and biophysical mechanisms underlying the selectivity, transport, and conformational dynamics of bacterial fluoride export proteins and copper/zinc transporters. The primary objectives of this 5-year project are to: 1) monitor the...
This Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $950,000 to The Research Foundation For The State University Of New York from February 2023 through January 2026. The award supports research into regulating iron homeostasis by controlling the fate of intracellular ferritin. A multidisciplinary team will use structural biology, spectroscopy, microscopy, proteomics, and other analytical tools to delineate the mechanisms determining...
This National Science Foundation Project Grant award of $997,716 provides funding from May 15, 2022 through April 30, 2026 to investigate the molecular mechanisms that maintain the integrity of the bacterial cell envelope under stress conditions. The award was made under the Biological Sciences program (CFDA 47.074) to the Research Foundation of the City University of New York at the City College of New York. Specifically, the awardee will examine how bacteria regulate the post-translational...