The University of Washington was awarded a $149,284 Project Grant by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the role of specific subpopulations of prefrontal cortex pyramidal neurons in regulating drug-seeking behavior. The research aims to elucidate the factors that predispose individuals to addiction and confer vulnerability to relapse, with the goal of advancing understanding of the functional roles of...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $252,714.59 to the University of California, Los Angeles (UCLA) to study the role of the basolateral amygdala in encoding inhibitory associations related to reward learning. The award will fund research to determine the temporal dynamics of basolateral amygdala activity during the development of inhibitory associations, assess whether...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under CFDA Program 93.279 - Drug Use and Addiction Research Programs, provides $162,672 in funding to the University of California, Los Angeles (UCLA) to conduct a study on the role of dopamine projections to the amygdala in goal-directed and habit learning. The research aims to use in vivo fiber photometry imaging and optogenetic manipulation techniques to characterize the function of the ventral tegmental area...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $232,128 to the Regents of the University of Minnesota to characterize the role of dopaminergic and glutamatergic mechanisms in the basolateral amygdala (BLA) that underlie dynamic drug-seeking behaviors. The research aims to measure in vivo dopamine signaling and D1-neuron activity in the BLA during cocaine self-administration, as well...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $818,513.00 to investigate the role of dopamine signaling in the basolateral amygdala on individual differences in reward-learning strategies and addiction-like behaviors. The 5-year study, starting on September 15, 2024, will focus on how Pavlovian reward-learning strategies, such as sign tracking versus goal tracking, predict unique...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $373,300 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the nucleus accumbens dynamics underlying cue-reward learning. The project aims to investigate how the brain selectively discriminates and responds to reward-predictive cues versus irrelevant ones, with a focus on the role of neuronal...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), will support research to explore the unique neurobehavioral profile of sequential opioid-stimulant polysubstance use disorders. The $314,225 award, effective July 31, 2024 through February 28, 2025, will fund a study conducted by the University of Washington to: 1) Define the behavioral profile of dual opioid-methamphetamine use disorders in a...
This federal Project Grant award for $340,000 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund research to better understand the role of the locus coeruleus-noradrenergic (LC-NE) system in fentanyl withdrawal-induced negative affect behaviors. The research aims to determine whether a newly identified midbrain glutamatergic input to the LC contributes to the negative affective behaviors associated with opioid withdrawal....
This $265,302 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to investigate the neural mechanisms underlying opioid use disorder (OUD) and relapse risk during abstinence. The funded project will map the functional and anatomical pathways between the anterior and posterior paraventricular nucleus of the thalamus (PVT) and the nucleus accumbens (NAc), which have been implicated in the...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $201,250 to New York University (NYU) to characterize the synaptic organization and connectivity of cholinergic interneurons in the nucleus accumbens core (NAc core) region of the mouse brain. The project aims to use anatomical, electrophysiological, and optogenetic techniques to investigate how diverse excitatory and inhibitory inputs contact...