The University of Pittsburgh is receiving a $1,076,036 Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) to characterize electroencephalography (EEG) signatures and interneuron function in the prefrontal cortex (PFC) related to opioid use disorder (OUD). The 5-year research project aims to define how neural activity within specific PFC interneuron subtypes contributes to EEG signatures associated with chronic opioid use and abstinence-related affective disturbances. The project will leverage a combination of fiber photometry calcium imaging, quantitative EEG, and electrophysiology to elucidate the underlying physiological mechanisms regulating PFC circuit function and OUD-related behaviors. The ultimate goal is to lay the groundwork for developing next-generation treatments targeting PFC interneurons for personalized OUD interventions.
Generated 3/4/25, 6:01 AM