Project Grant F31DA064363
- This federal Project Grant award of $613,786.00 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is supporting research to elucidate the molecular, cellular, and physiological consequences of D1 dopamine receptor (D1DR) signaling from both the plasma membrane and Golgi compartments in primary medium spiny neurons. The research aims to advance understanding of the role of compartmentalized D1DR signaling in the neurobiology...
- This federal Project Grant award of $201,250 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research on the synaptic organization of cholinergic interneurons in the nucleus accumbens region of the brain. The study, conducted by New York University (NYU), aims to characterize the diverse excitatory and inhibitory inputs that contact these interneurons and influence their firing patterns. The research combines...
- This $480,000 Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop new tools to facilitate the study of how drugs of abuse interact with G protein-coupled receptors (GPCRs) and alter their signaling. The key products and services to be delivered under this 5-year grant include: Generation of chemical biology tools to enable time-resolved cryogenic electron microscopy imaging of GPCR...
- This federal Project Grant award for $613,017.00, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to examine the interdependent neural circuit mechanisms underlying the timing of dopamine reward omission signals and striatal dynamics in mice. The project, conducted by the University of California, Los Angeles (UCLA), aims to elucidate how dopamine and striatal timing processes interact to enable...
- This federal Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) provides $226,608.00 to support research on dissecting the mechanisms of dopamine transmission and its roles in reward-related behaviors. The research will investigate how dopamine signaling occurs at the subcellular level and the implications for neuropsychiatric diseases and substance abuse disorders. The grant was awarded to the University of Colorado-Denver on...
- This federal Project Grant award of $180,606.00 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund research at the Icahn School of Medicine at Mount Sinai to investigate the interplay between drug-induced long-term synaptic proteomic adaptations and the underlying transcriptional responses that drive these adaptations in a cell-type and circuit-specific manner within the brain's reward regions. The research aims to...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, supports research under the Drug Use and Addiction Research Programs (CFDA 93.279) on the interplay between norepinephrine and dopamine circuits in the brain and their role in sex differences in reward and aversion. The $781,032 award, spanning August 2025 to April 2030, will map the anatomical and neurochemical distribution of norepinephrine projections from the locus...
- The University of Washington was awarded a $149,284 Project Grant by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the role of specific subpopulations of prefrontal cortex pyramidal neurons in regulating drug-seeking behavior. The research aims to elucidate the factors that predispose individuals to addiction and confer vulnerability to relapse, with the goal of advancing understanding of the functional roles of...
- This two-year, $140,108 project grant from the National Institutes of Health's National Institute of Neurological Disorders and Stroke will fund research into the co-regulation of striatal dopamine and acetylcholine in associative reward learning. The grantee, The Trustees of Columbia University in the City of New York, will investigate how these two neuromodulators interact to drive associative reward learning processes. Specifically, the researchers will test the hypothesis that striatal...
- This $1,039,420 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research to study the neuronal ensembles and circuits involved in the facilitation and disinhibition of opioid and alcohol seeking behaviors. The 5-year project, which begins on June 1, 2025 and runs through February 28, 2030, will employ innovative techniques such as single-nucleus RNA sequencing, spatial sequencing, and in vivo...
DOPAMINERGIC MODULATION OF NMDA RECEPTOR SIGNALING IN THE NUCLEUS ACCUMBENS - PROJECT SUMMARY ALTERATIONS IN BOTH DOPAMINE (DA) AND GLUTAMATE SIGNALING IN THE NUCLEUS ACCUMBENS (NAC) ARE THOUGHT TO PLAY A KEY ROLE IN SUBSTANCE USE DISORDERS AND ADDICTION. DA REGULATES NAC CIRCUIT ACTIVITY BY MODULATING GLUTAMATERGIC TRANSMISSION AND RECEPTOR ACTIVITY, HOWEVER, THE PRECISE MECHANISMS REMAIN UNCLEAR. SYNAPTIC PLASTICITY AND REGULATION OF INTRACELLULAR EXCITABILITY IS PRIMARILY ATTRIBUTED TO THE FUNCTIONS OF GLUTAMATERGIC NMDA RECEPT ORS (NMDARS). HOW DOPAMINE RECEPTORS REGULATE NMDAR ACTIVITY AND HOW THIS DIFFERS BETWEEN SYNAPTIC CONNECTIONS IN ACCUMBAL CIRCUITRY REMAIN IMPORTANT QUESTIONS. THIS PROPOSAL WILL UTILIZE EX VIVO SLICE ELECTROPHYSIOLOGY IN COMBINATION WITH OPTOGENETICS AND IONTOPHORESIS IN TRANSGENIC MOUSE LINES TO INVESTIGATE THE SYNAPSE SPECIFICITY AND INTRACELLULAR SIGNALING MECHANISMS UNDERLYING DA RECEPTOR REGULATION OF NMDAR CURRENT IN BOTH D1 AND D2 TYPE DOPAMINE RECEPTORS. UNDERSTANDING THE SYNERGISTIC ROLE OF D1 AND D2 RECEPTOR SIGNALING IN REGULATING GLUTAMATE TRANSMISSION AND RECEPTOR ACTIVITY IN THE NAC IS A CRITICAL STEP IN THE INVESTIGATION OF BOTH MOTIVATION AND THE DYSFUNCTIONS THAT ARISE IN THIS SYSTEM AFTER EXPOSURE TO DRUGS OF ABUSE.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $41.3k | 7/7/25 |