Project Grant F31CA310602
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Leland Stanford Junior University a Project Grant of $235,815 under the Cancer Research Manpower program (CFDA 93.398) to support research training and workforce development in cancer research. The award, which commenced August 1, 2025, and concludes July 31, 2027, funds a research project titled "Harnessing Multi-Modal and Multi-Omics Data Integration to Decipher Therapeutic Response in Non-Small Cell...
- Federal Grant Award Summary The National Cancer Institute awarded The Leland Stanford Junior University a Project Grant of $137,266 under the Cancer Research Manpower program (CFDA 93.398) for the period July 1, 2026 through June 30, 2028. This award supports comprehensive profiling research focused on developing personalized interventions for T-cell lymphoma (TCL), a malignancy with high relapse rates and poor prognosis. The project delivers three integrated research components: (1) development...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Stanford University a $130,932 Project Grant under the Cancer Research Manpower program (CFDA 93.398) on December 18, 2025, to support research and workforce development activities through September 30, 2028. The grant funds a research project titled "Determining the Spatial Contexts that Modulate Immune Cell Phenotypes in Colorectal Cancer," which aims to identify predictive biomarkers for immunotherapy response...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Leland Stanford Junior University a Project Grant of $158,499 under the Cancer Research Manpower program (CFDA 93.398) for research investigating the role of CDKN2A in lung adenocarcinoma metastasis. The award, obligated on May 15, 2026, with a completion date of April 30, 2028, supports research utilizing CRISPR-Cas9 somatic genome editing and tumor barcoding to develop novel metastasis assay models in...
- Federal Grant Award Summary The National Cancer Institute awarded The Leland Stanford Junior University a $584,521 Project Grant on August 8, 2025, under the Cancer Treatment Research program (CFDA 93.395) to investigate subclonal determinants of radiation response in soft tissue sarcomas. The research will deliver three primary products: (1) identification and validation of epigenetic changes, including DNA methylation and chromatin accessibility alterations, that confer radioresistance to...
- Federal Grant Award Summary The National Cancer Institute awarded The Leland Stanford Junior University a $368,294 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for the period September 1, 2025 through August 31, 2028. This award supports the development of next-generation platforms for interrogating T cell receptor (TCR) specificity to identify and detect tumor antigens at the protein level. The project addresses a critical bottleneck in cancer...
- Federal Project Grant Award Summary The National Cancer Institute awarded a Project Grant of $357,370 to The Leland Stanford Junior University on May 5, 2026, under the Cancer Treatment Research program (CFDA 93.395) to support a five-year research initiative through April 30, 2031. The project, titled "Reprogramming Inflammatory Fibroblasts to Overcome Therapeutic Resistance in Pancreatic Adenocarcinoma," focuses on developing novel therapeutic approaches to address pancreatic...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Leland Stanford Junior University a $635,340 Project Grant under the Cancer Cause and Prevention Research program (CFDA 93.393) on May 4, 2026, with completion targeted for April 30, 2031. This grant funds functional genomic research to dissect lung cancer mechanisms through an integrated approach combining genetically engineered mouse models, multiplexed CRISPR-based genome editing, and tumor barcoding technologies. The...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the Regents of the University of Michigan $175,448 under the Cancer Research Manpower program (CFDA 93.398) on January 16, 2026, with completion targeted for July 31, 2027. This project grant supports research training and investigator development in cancer biology, specifically focused on characterizing cancer-associated fibroblasts (CAFs) and their role in pancreatic ductal adenocarcinoma (PDAC). The research aims to...
- Award Summary The National Cancer Institute (NCI) awarded a Cooperative Agreement totaling $1.92M to The Leland Stanford Junior University for fundamental research under the Cancer Biology Research program (CFDA 93.396). Commencing July 25, 2025, and extending through May 31, 2030, this award funds a systems-level investigation into pancreatic ductal adenocarcinoma (PDAC) metastasis, specifically addressing the molecular determinants governing metastatic ability, organ tropism, and immune...
The National Cancer Institute (NCI) awarded The Leland Stanford Junior University a Project Grant of $100,228.00 under the Cancer Research Manpower program (CFDA 93.398) to support biomedical research training and workforce development in cancer research. The award, obligated on December 1, 2026, with an ultimate completion date of June 30, 2029, funds research investigating the regulation of early breast cancer invasion by cancer-associated fibroblasts (CAFs). The project addresses the critical transition from ductal carcinoma in situ (DCIS)—a non-invasive lesion—to invasive breast cancer (IBC) by examining how tumor microenvironment alterations, particularly CAF activation and extracellular matrix stiffness, drive disease progression. The research deliverables include ex vivo and in vitro analyses to characterize transcriptomic, proteomic, and mechanical features associated with CAF populations and their correlation with invasive progression. Specifically, the project will establish correlative relationships between CAF phenotype and matrix mechanics in patient samples (Aim 1) and identify causal mechanisms through advanced perturbation techniques in a three-dimensional stromal model (Aim 2). The research seeks to validate the hypothesis that CAF-driven matrix remodeling through fibronectin secretion and collagen bundling creates a mechanical niche that drives carcinoma invasion, with preliminary single-cell sequencing data and in vitro modeling confirming CAF mechanoresponsiveness and their necessity in facilitating carcinoma invasion.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 5/14/26 | ||
| Not listed | $50.1k | 5/14/26 | ||
| Not listed | $50.1k | 5/14/26 |