Project Grant K99CA312806
- Federal Project Grant Award Summary The National Cancer Institute awarded The Leland Stanford Junior University a Project Grant of $635,340 (awarded May 4, 2026, with completion targeted for April 30, 2031) under the Cancer Cause and Prevention Research program (CFDA 93.393) to conduct functional genomic dissection of lung cancer in vivo. The research delivers comprehensive analysis of tumor suppressor gene function through an integrated approach combining genetically engineered mouse models,...
- Federal Project Grant Award Summary The Leland Stanford Junior University received a $135,774 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398) on July 10, 2025, with a completion date of June 30, 2027. This award supports research training and investigation into tumor suppressor genes (TSGs) and the overdominant model of tumor suppression in oncogenic KRAS-driven lung adenocarcinoma. The research employs advanced molecular and...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Leland Stanford Junior University a Project Grant of $119,172.00 under the Cancer Research Manpower program (CFDA 93.398) to support research addressing therapeutic response in non-small cell lung cancer (NSCLC). The project, initiated August 1, 2025, and completing July 31, 2027, focuses on developing computational approaches to integrate multi-modal and multi-omics biomedical datasets for improved...
- Summary of Cooperative Agreement Award The National Cancer Institute (NCI) awarded a $1.28 million Cooperative Agreement under the Cancer Biology Research program (CFDA 93.396) to The Leland Stanford Junior University on July 25, 2025, for research spanning through May 31, 2030. The research initiative, titled "Multiplexed Dissection of Metastatic Ability, Organ Tropism, and Immune Evasion," focuses on understanding how diverse pancreatic ductal adenocarcinoma (PDAC) cell states...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Leland Stanford Junior University a Project Grant of $133,598.00 under the Cancer Research Manpower program (CFDA 93.398) on June 23, 2025, with completion anticipated by May 31, 2027. This award supports research aimed at developing improved chemoprevention strategies for Familial Adenomatous Polyposis (FAP), a hereditary condition characterized by polyp formation and elevated cancer risk. The principal...
- This $1,480,500 federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) aims to elucidate the cell intrinsic and extrinsic mechanisms underlying small cell lung cancer (SCLC) metastasis. The project will develop cutting-edge technologies to establish a comprehensive, spatiotemporally-resolved lineage tracing platform capable of recording the entire course of SCLC metastasis. Specifically, the...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $141,195 Project Grant under the Cancer Research Manpower program (CFDA 93.398) to The University of Texas MD Anderson Cancer Center for research titled "Deciphering the Role of Tumor Suppressor Gene Deficiencies in Modulating PDAC Response to Oncogenic KRAS Inhibition and Immunotherapy." The award was obligated on May 15, 2026, with a completion date of April 30, 2028. This funding supports a K99/R00 Pathway...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a $195,240 Project Grant under the Cancer Research Manpower program (CFDA 93.398) to Massachusetts General Hospital, effective September 17, 2025, with completion targeted for August 31, 2030. This K25 career development award supports the development of a single-cell assay platform that correlates genomic, transcriptomic, and dynamic behavioral data of metastatic cancer cells in an in vivo mouse model using laser...
- Federal Project Grant Award Summary New York University School of Medicine received a $315,246 Project Grant award from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398), effective August 1, 2025, through July 31, 2030. This five-year research initiative, titled "Breaking Cytokine Loops in Lung Adenocarcinoma," will deliver fundamental cancer research and scientific investigation focused on understanding immune resistance mechanisms in lung cancer...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $102,984 to The Trustees of Columbia University in the City of New York (Health Sciences Division) on December 25, 2025, under the Cancer Research Manpower program (CFDA 93.398). The award, with an ultimate completion date of June 30, 2028, supports research titled "Spatiotemporal Resolution of Niche and Genomic Co-Evolution in Brain-Metastatic Organotropism." The project aims to...
This Project Grant, awarded by the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398) on May 15, 2026, supports research investigating the role of CDKN2A in lung adenocarcinoma metastasis at The Leland Stanford Junior University. With $158,499 in obligated federal funding through April 30, 2028, the award funds a two-year research initiative employing CRISPR-Cas9 somatic genome editing and tumor barcoding technologies to develop and validate novel metastasis assays in genetically engineered mouse models. The research aims to elucidate the functional mechanisms by which CDKN2A inactivation promotes metastatic colonization and growth in KRAS-driven lung adenocarcinoma and explore how complex tumor genotypes drive metastatic spread to distant organs. The deliverables include comprehensive profiling of metastatic cell states in CDKN2A-deficient tumors, functional dissection of the constituent CDKN2A genes (INK4A and ARF), systematic mapping of complex genotypes to specific metastatic phenotypes, and investigation of the MTAP/CDKN2A/CDKN2B locus frequently deleted in human cancers. The project employs a CAS12A transgenic mouse platform developed by the investigator to enable efficient multi-locus targeting and evaluate targeted therapeutic approaches. These research outputs are intended to advance understanding of lung cancer metastasis mechanisms and inform development of new therapeutic interventions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $158.5k | 5/18/26 |