Project Grant F32CA301657
- This federal Project Grant award of $128,199 from the National Cancer Institute's Cancer Research Manpower program (CFDA 93.398) supports research by the Regents of the University of Michigan to investigate the role of the lipid kinase PIKFYVE in regulating metabolic homeostasis in pancreatic ductal adenocarcinoma (PDAC). The research aims to 1) dissect PIKFYVE's function in PDAC metabolism, and 2) determine the mechanism and efficacy of combining PIKFYVE inhibition with KRAS-MAPK inhibition...
- This Project Grant award from the National Cancer Institute (NCI), under the 21st Century Cures Act - Beau Biden Cancer Moonshot (CFDA 93.353) program, provides $435,144 to investigate the role of endoplasmic reticulum (ER) stress in activating and sustaining cancer-associated fibroblasts (CAFs) in pancreatic ductal adenocarcinoma (PDAC). The research, conducted by a collaborative partnership between Henry Ford Health and Michigan State University Health Sciences, aims to understand how ER...
- This $150,104 Project Grant award from the National Cancer Institute's Cancer Research Manpower program (CFDA 93.398) supports research to understand the evolutionary trajectories of complex genomic rearrangements in cancer. The project aims to develop novel computational approaches, "AGAVE" and "ROSE", to characterize the timing and dynamics of focal amplifications and structural variants during tumor evolution. The research will map these evolutionary patterns across...
- This Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) provides $101,340.00 to the Regents of the University of Michigan to conduct research focused on understanding the role of the MS4A14 protein in regulating macrophage activation and its impact on anti-tumor immunity. The award period runs from Dec 12, 2025 to Jun 16, 2028. The research aims to investigate how MS4A14 expression in macrophages influences their ability to present antigens and...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $509,246 to the Regents of the University of Michigan to conduct research on early drivers of prostate cancer lineage plasticity. The project aims to identify key transcriptional regulators that repress androgen receptor signaling and promote alternate differentiation programs in prostate cancer, with the goal of preventing lineage plasticity and disease progression. By...
- The National Institutes of Health's National Cancer Institute awarded a $283,136 Project Grant to the Regents of the University of Michigan under the Cancer Research Manpower federal grant program (CFDA 93.398). The award will support research investigating cellular communication in the tumor microenvironment of pancreatic cancer. The grantee will examine how hedgehog signaling alters the immune landscape and endothelial cell function through fibroblast interactions. They will also determine the...
- The federal Project Grant award in the amount of $159,304 was provided by the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398). The award was granted to the Dana-Farber Cancer Institute, Inc. (DFCI) to support research on signaling pathways in tumoricidal macrophages in pancreatic cancer. The key objectives of the project include defining the role of deubiquitinases in regulating macrophage surface receptors that govern the recognition and phagocytosis...
- This Cooperative Agreement awarded by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $1,281,520.00 in funding to The Leland Stanford Junior University to conduct research on the fundamental biological mechanisms of cancer metastasis, organ tropism, and immune evasion. The project aims to integrate genetic barcoding with single-cell profiling to uncover the key molecular drivers underlying metastatic fitness and diverse cancer cell states in pancreatic ductal...
- This $410,115 Project Grant was awarded by the National Cancer Institute, under the Cancer Biology Research program (CFDA 93.396), to the University of California, San Diego (UC San Diego) to support research aimed at improving preclinical models of metastatic pancreatic cancer. The research project seeks to understand how the collagen-rich tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) drives metastasis and treatment resistance, and to develop a synthetic 3D high density...
- This $151,263 federal Project Grant award was provided by the National Cancer Institute under the Cancer Research Manpower (CFDA 93.398) program to fund a research project titled "Understanding Paracrine Interactions Induced by Morphogens in PDAC" at The Trustees of Columbia University in the City of New York. The project aims to identify how active morphogen signaling shapes local immunosuppression in the pancreatic tumor microenvironment by studying the interactions between malignant...
This federal Project Grant award from the National Cancer Institute's (CFDA 93.398) Cancer Research Manpower program provides $175,448 to the Regents of the University of Michigan to conduct research on characterizing the evolution, programming, and crosstalk of cancer-associated fibroblasts (CAFs) in pancreatic ductal adenocarcinoma (PDAC). The objectives are to (1) characterize the evolution of fibroblasts from normal pancreatic tissue to adenocarcinoma, and (2) dissect the effects of fibroblast polarization by PDAC and assess subtype-specific programming. This work aims to generate a temporal map of CAF evolution and clarify subtype-specific tumor microenvironment features to help develop new therapies for this deadly form of cancer. The award period runs from January 16, 2026 through July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $87.7k | 7/15/25 | ||
| Not listed | $87.7k | 7/15/25 | ||
| Not listed | $0 | 7/15/25 |