Project Grant R33CA302206
- This Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) to The Leland Stanford Junior University totals $170,376.00 and is focused on developing a rapid, label-free, and cost-effective technique for Chimeric Antigen Receptor (CAR) T cell quantification in patient blood using Surface Enhanced Raman Spectroscopy (SERS) and Machine Learning (ML). The key products and services to be delivered under this award include: Optimizing a SERS...
- This Project Grant award from the Department of Health and Human Services National Institutes of Health (CFDA 93.310 Trans-NIH Research Support) provides $1,400,954.00 to The Leland Stanford Junior University to conduct research on combinatorial engineering of multicellular synthetic immunotherapy systems. The research program aims to: (1) co-optimize chimeric antigen receptors (CARs) and synthetic cytokine receptors (SCRs) to enhance anti-tumor immune cell function; (2) co-engineer T cells,...
- This federal Project Grant award of $640,522 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to The Leland Stanford Junior University supports research to elucidate how microbial microproteins modulate macrophage function, a critical coordinator of tumor immune response. The project aims to carry out high-throughput screens of thousands of microbial macromolecules to identify those that directly modulate macrophages, with the goal of enhancing cancer immunotherapy...
- This $414,803 Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) supports research by the Massachusetts Institute of Technology (MIT) to develop improved T cell receptor (TCR) engineering strategies for TCR-T cell cancer immunotherapy. The key products and services to be delivered under this grant include: Implementing high-throughput library screens of TCR constant region variants to identify mutations that can improve TCR signaling strength, with...
- The National Institutes of Health, National Cancer Institute awarded a $140,433 Project Grant to The Leland Stanford Junior University under the Cancer Research Manpower (CFDA 93.398) program. The award will be used to generate CD19.28Z chimeric antigen receptor (CAR) T cells in vivo using a Programmable Antibody-mediated Cellular Knock-in of T cells (PACK-IT) system. The goals are to optimize the PACK-IT system, compare the resulting PACK-IT CAR-T cells to conventionally manufactured CAR-T...
- The Leland Stanford Junior University was awarded a $1,108,391.72 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) with a project period from January 1, 2025 to December 31, 2027. The grant supports research to define the most therapeutically relevant CAR T cell subsets in patients with large B cell lymphoma (LBCL) and overcome immune suppression mechanisms of resistance to CAR T cell therapy. Key research activities include following...
- This federal Project Grant award of $672,371.00 from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394) supports research at Yale University to develop ultra-sensitive mass spectrometry-based immunopeptidomics using digital microfluidics. The project aims to improve the identification of tumor-specific antigens (TSAs) to support the development of effective cancer immunotherapies. The award has a performance period from September 1, 2025...
- This Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) provides $135,594.00 to The Leland Stanford Junior University to develop novel pharmacological approaches to rewire oncogenic gene expression and induce cancer cell death. The primary objectives are to: Develop small molecule chemical inducers of proximity (CIPs) that can potently activate pro-apoptotic gene expression and kill aggressive leukemias driven by MLL gene translocations. This will...
- This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to Pumpkinseed Technologies Inc. for $353,204 supports the development and demonstration of a novel technology called Cell-MAPP. The goal of this Phase I SBIR project is to create the first system capable of continuously monitoring the state transitions of individual T cells in response to antigen exposure. Cell-MAPP will utilize antigen-multimer barcoding and single-cell TCR sequencing to connect...
- This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research by the University of California, San Francisco (UCSF) to genetically engineer myeloid cells, including macrophages and dendritic cells, for the treatment of solid tumors. The $0.00 award, with a project period from August 1, 2025 to July 31, 2028, aims to apply advanced genetic engineering tools to reprogram myeloid cells and enhance their tumoricidal activities and resistance to...
This Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) supports the development of "Next Generation Platforms for Interrogating TCR Specificity" at The Leland Stanford Junior University. The $368,294 award spanning 9/1/2025 to 8/31/2028 will optimize two complementary methods to identify, detect, and target peptide-MHC tumor antigens. This includes improving a yeast peptide-MHC display platform to discover new tumor antigens and developing experimental and computational platforms to rapidly isolate high-affinity "TCR mimic" antibodies and mini-binders that can track tissue expression and selectively kill cells expressing these antigens. The research aims to advance technologies that can interrogate and mimic how T cell receptors recognize peptide-MHC complexes to enable more effective antigen-specific cancer immunotherapies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $368.3k | 8/25/25 |