This $3.63 million Project Grant from the Department of Health and Human Services National Institutes of Health Office of the Director, under the Trans-NIH Research Support program (CFDA 93.310), will fund research at Duke University from August 2022 through July 2025 to develop predictive dynamic models of the functional connectivity underlying visually guided behavior in zebrafish. Using integrated optical imaging, optogenetic manipulation, and recurrent neural network techniques, the...
The Department of Health and Human Services National Institutes of Health (NIH) awarded Duke University a $1,425,761 Project Grant under the Trans-NIH Research Support (CFDA 93.310) federal grant program. The purpose of this 3-year award is to harness stem cells and synthetic gene circuits to repair glomerular injury and address the significant burden of chronic kidney disease (CKD) and end-stage kidney disease (ESKD) in the U.S. and worldwide. The research will leverage Duke's expertise in...
The National Institute of General Medical Sciences (NIGMS) awarded a $387,500 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to The Johns Hopkins University to conduct research on gene regulatory networks for hair cell regeneration. The project aims to elucidate how Sox and Six transcription factors control hair cell regeneration in zebrafish, with the goal of gaining insights into the molecular mechanisms regulating this process and its implications for triggering a...
Yale University was awarded a $3,015,000 Project Grant from the Department of Health and Human Services National Institutes of Health Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) for the period of September 15, 2022 through August 31, 2025. The grant will support research to develop a controllable and scalable in vitro model for studying human embryonic patterning and germ layer differentiation using human pluripotent stem cells and bioengineering...
This $1,383,800 federal Project Grant award from the Department of Health and Human Services' National Institutes of Health, under the Trans-NIH Research Support (CFDA 93.310) program, supports the University of Pittsburgh's research to develop new methods for creating and testing developmental signaling patterns. The project aims to leverage high-throughput optogenetic manipulation to build libraries of paired data on developmental signaling patterns and resulting tissue structures. This...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 - Child Health and Human Development Extramural Research provides $487,559 to Yale University to conduct research on the molecular biophysics and systems morphogenesis in early spinal column development. The key research objectives are to quantify the molecular dynamics of single integrin heterodimers, which mediate cell-extracellular matrix (ECM) adhesion, in the neural...
This $1,145,674 federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), part of the National Institutes of Health (NIH), will fund research at Case Western Reserve University to investigate the role of TMC proteins in hair cell mechanotransduction in zebrafish. Specifically, the project aims to determine if TMCs contribute differently to zebrafish hearing, the role of TMCs in hair cell mechanotransduction and lateral line-mediated...
This $409,750 Project Grant award was made on June 5, 2025 by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant aims to discover mechanisms underlying the role of the small molecule serotonin (5-HT) in controlling spine morphology and development, with the goal of providing a framework for treating spinal deformities like adolescent idiopathic scoliosis. Using zebrafish as a model...
This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $682,219 to Duke University to conduct research aimed at defining the mechanisms driving olfactory neuronal homeostasis and dysfunction in humans. The key products or services to be delivered under this award include: 1) Establishing the axes of transcriptional variation in human...
The University of Miami was awarded a $767,494 five-year Project Grant (R01DC022239) from the National Institute on Deafness and Other Communication Disorders (CFDA 93.173) to develop human induced pluripotent stem cell-derived inner ear organoid platforms for testing gene therapies and treatments for genetic hearing and balance disorders. The project aims to establish human inner ear organoid models to evaluate the cellular consequences of CRISPR/Cas9-based gene editing strategies for...
The Department of Health and Human Services (HHS) National Institutes of Health (NIH) awarded a $1,319,060 Project Grant to Duke University under the Trans-NIH Research Support (CFDA 93.310) program. The grant, effective September 1, 2023 through August 31, 2026, will fund research to study the robust formation of organs, with a focus on the development of the semicircular canals in the inner ear of zebrafish. The research aims to measure variations in tissue patterns, investigate the respective contributions of genetic instructions and other regulatory mechanisms, and systematically study the physical constraints from tissue geometry and mechano-transduction during embryonic development. The goal is to establish an integrative framework that captures the reciprocal flow of information between genetic patterns, cell behaviors, and tissue geometry for successful organ morphogenesis. This research may provide insights into the underlying causes of developmental defects and disorders, potentially impacting human healthcare in the long term.