This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $409,750 to the University of Oregon to conduct research on the role of serotonin (5-HT) in controlling spine morphology and preventing spinal deformities. The key objectives of this 1-year research project are to: 1) perform spatial and temporal genetic perturbations to determine when and where 5-HT functions to control spine morphology, and 2) investigate the roles of 5-HT in regulating Reissner fiber formation, subcommissural organ gene expression, and notochord patterning - pathways known to influence spine development. This work leverages the university's expertise in using zebrafish as a model system to mechanistically link 5-HT signaling to the prevention of spinal deformities, with the goal of identifying potential non-invasive treatment approaches for conditions like adolescent idiopathic scoliosis.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $409.8k | 6/3/25 |