The National Science Foundation awarded a $1,064,877 project grant to the University of Pittsburgh under the Engineering program (CFDA 47.041) to support research titled "COLLABORATIVE RESEARCH: RECODE: DIRECTED DIFFERENTIATION OF HUMAN LIVER ORGANOIDS VIA COMPUTATIONAL ANALYSIS AND ENGINEERING OF GENE REGULATORY NETWORKS." The three-year award beginning January 1, 2022 will fund development of computational models to analyze gene regulatory networks and direct differentiation of human...
The Department of Health and Human Services (HHS) National Institutes of Health (NIH) awarded a $1,319,060 Project Grant to Duke University under the Trans-NIH Research Support (CFDA 93.310) program. The grant, effective September 1, 2023 through August 31, 2026, will fund research to study the robust formation of organs, with a focus on the development of the semicircular canals in the inner ear of zebrafish. The research aims to measure variations in tissue patterns, investigate the respective...
This federal Project Grant award of $329,834 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will fund research at William Marsh Rice University to visualize and understand how extracellular morphogens, specifically the Nodal signaling pathway, shape embryonic development and cell fate patterning. The research will leverage CRISPR-edited human pluripotent stem cells to...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is focused on dissecting the input-output relationships of developmental BMP signaling. The $104,838 award to Duke University will support research that aims to shed light on how cells perceive and respond to varying BMP signaling inputs, with the goal of uncovering fundamental principles of cell...
The National Institute of Child Health and Human Development (NICHD) awarded The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania, a $162,500 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) on September 22, 2023. The grant supports the development of tools to visualize the construction and assembly of the Posterior Signaling Center (PSC), a cell niche that controls the progenitors of insect...
This Project Grant award, valued at $293,756, was provided by the National Institutes of Health (NIH) under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the Institute for Systems Biology (ISB). The funding will support research to enhance understanding of placental dysfunction in common obstetric disorders like preeclampsia, preterm birth, and fetal growth restriction. The research aims to identify molecular mechanisms and network-level patterns...
This Project Grant award, valued at $142,996.00, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The funding supports research to investigate how migrating cells can influence the morphogenesis and directional growth of their extracellular matrix substrate, using the Drosophila caudal visceral mesoderm and trunk visceral mesoderm as a model system. The research aims to...
Yale University was awarded a $3,015,000 Project Grant from the Department of Health and Human Services National Institutes of Health Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) for the period of September 15, 2022 through August 31, 2025. The grant will support research to develop a controllable and scalable in vitro model for studying human embryonic patterning and germ layer differentiation using human pluripotent stem cells and bioengineering...
This $325,044 federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports research to develop a new "aerodynamic fiber deposition" technology to manufacture biomimetic soft fiber-reinforced composites with spatially varying fiber arrangements. The research aims to enable the production of high-throughput, highly controlled nano/microfiber patterns that mimic the complex fiber structures found in biological tissues like skin, muscle, and...
The National Institutes of Health's Office of the Director awarded a $2,925,000 Project Grant to The Trustees of the University of Pennsylvania under the Trans-NIH Research Support program (CFDA 93.310) to develop genomic tools for massively parallel recording of signaling activity at cellular resolution in a brain-wide manner. The University of Pennsylvania will utilize CRISPR/Cas tools to record signaling inputs in each cell's genome and analyze these signals at high-throughput using...