Project Grant DP2AI184835

Award Date 8/15/24
Completion Date 7/31/29
Dollars Obligated $926K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
St. Louis, MO 63110, USA
Similar Awards
This Project Grant award of $222,750 from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 - Allergy and Infectious Diseases Research, will support research on the role of the Fc fragment of IgG binding protein (FcGBP) in the intestinal mucus layer and its impact on gut microbiota composition. The primary goals are to determine how FcGBP contributes to the glycosylation and sialylation of the colon mucus layer, and how this affects the abundance of specific...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $891,678 to the Scripps Research Institute in La Jolla, CA to conduct research on how metabolites from the intestinal microbiota can modulate host immune responses. The researchers will employ chemical biology and proteomics methods to identify specific microbiota-associated bile acid protein targets in mammalian cells...
This federal Project Grant award of $195,213 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research by the University of California, Davis to investigate the mechanisms by which the gut microbiota, specifically short-chain fatty acids, can inhibit the growth of the enteric pathogen Yersinia enterocolitica. The research aims to elucidate the molecular mechanisms underlying Y. enterocolitica's sensitivity and...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is focused on elucidating the role of Akkermansia muciniphila in Group B Streptococcal (GBS) vaginal colonization and ascending infection. The $148,568 award will support research to investigate the specific mechanisms by which A. muciniphila promotes GBS interaction with human vaginal epithelial cells, potentially...
This $4,908,988 Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Yale University. The grant supports research to investigate the mechanisms by which gut microbiota and white adipose tissue control the CD4 T-cell compartment and facilitate the trafficking of these immune cells from the gut to the brain. The research aims to elucidate the gut-brain axis and its role in...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a 2-year Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) worth $162,000 to The Johns Hopkins University to study how atypical B cells can be used to enhance vaccine responses in immunosuppressed individuals. The research project aims to define populations of immunosuppressed individuals who utilize these atypical CD11c+ B cells, assess their interaction with T cells, and target fatty acid oxidation...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a 5-year, $571,091 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to President and Fellows of Harvard College, doing business as Harvard Medical School, to investigate the role of gut regulatory T (Treg) cells and their interactions with the gut microbiome. The research aims to understand how microbial and food antigens establish gut Treg phenotypes and T cell receptor repertoires, particularly...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $226,641 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Colorado-Denver. The grant, awarded on December 5, 2024 with a completion date of November 30, 2026, will support research to examine how the intestinal microbiome and the pattern recognition receptor NOD2 expressed in intestinal epithelial cells impact pathogenesis of Coxsackievirus B3, an enteric virus...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $479,730 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Wisconsin - Madison. The 5-year grant, effective from December 1, 2024 to November 30, 2029, will support research to elucidate the mechanisms by which prophages (viral DNA) in the gut symbiont Limosilactobacilus reuteri modulate the production of the antimicrobial compound reuterin. The research aims to...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $582,350 to the University of Illinois to conduct research on microbiota-mediated colonization resistance to Acinetobacter baumannii. The goal is to identify keystone gut microbial species that can synergize with a diverse microbiota to prevent colonization by this opportunistic pathogen, which poses a...

This $926,057 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research is supporting research to understand how the gut microbiota influences immune responses, particularly B-cell development and antibody production, following vaccination. The project aims to identify gut stromal cell populations and microbial components that are crucial for enhancing stromal cell function and promoting improved vaccine responses. The research will leverage a gnotobiotic mouse model colonized with human-derived microbiota to investigate the microbiota-stromal cell axis and its impact on vaccine efficacy, with the goal of developing novel microbiota-targeted interventions to boost vaccine effectiveness, especially in vulnerable populations. The 5-year project period runs from August 2024 through July 2029 and is being conducted by the Washington University in St. Louis.

Generated 8/5/25, 4:45 AM