The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $222,750 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of Alabama at Birmingham (UAB) to conduct research on the "Novel Roles of Fc Gamma Binding Protein in Colonic Host-Microbiota Interactions." The two-year grant, running from May 1, 2025 to April 30, 2027, will fund research to determine the contribution of the Fc fragment of IgG binding protein (FcgBP) to the structure and glycosylation of the colon mucus layer, and how this affects the abundance of specific gut bacteria. The research will also explore the immune pathways deployed to limit inflammation when FcgBP expression is suppressed, and the potential connections to disease susceptibility in the large intestine. If successful, the studies will define novel functions for FcgBP in intestinal immune homeostasis and identify key mechanisms linking reduced FcgBP to increased risk of colon inflammation and cancer.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $222.8k | 4/28/25 |