Project Grant R21AI188307

Award Date 11/8/24
Completion Date 10/31/26
Dollars Obligated $195K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Davis, CA, USA
Similar Awards
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $891,678 to the Scripps Research Institute to conduct research on how metabolites from the intestinal microbiota can modulate host immune responses. The key objectives are to employ innovative chemical biology and proteomic methods to identify protein targets of microbiota-associated bile acids in mammalian...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $242,310 to Duke University to investigate the mucin utilization capabilities of the gut microbe Akkermansia muciniphila. The research aims to identify the genes and biological mechanisms enabling A. muciniphila to thrive within the gastrointestinal mucin layer, including processes for binding, importing, and degrading...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $220,340 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Carnegie Institution of Washington for the project "Coordinated Growth in Microbial Communities and Implications for Antibiotic Sensitivities". This research aims to understand how cross-phylum signals between Lactiplantibacillus plantarum and Acetobacter species affect cellular physiology and antibiotic...
This $242,310 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to understand how the commensal microbiota are trafficked to the thymus and presented to developing T cells during early life. The research aims to elucidate the mechanisms by which the intestinal environment and maternal antibodies selectively filter and transport specific commensal antigens to...
This $2,734,799 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research on the respiration and fitness of Bacteroides bacteria in the human gut. The key objectives are to study the NUO respiratory complex, menaquinone biosynthesis, and the NRFHA complex in Bacteroides to better understand their energy generation processes and how they support bacterial fitness in the gut...
This $502,500 project grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award will fund research to elucidate the molecular mechanisms underlying ferrosome organelle biogenesis in the bacterium Clostridioides difficile, which is a leading cause of antibiotic-associated intestinal infections. The research aims to define how the ferrosome system enables C. difficile to adapt to iron...
This federal Project Grant award for $637,275 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to uncover the mechanisms behind how gram-negative bacterial pathogens rapidly develop tolerance to chemical stressors like antibiotics. The research aims to determine how bacteria can inhibit the functioning of existing porin proteins in their outer membrane within minutes of exposure to...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $126,096 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of California, San Diego (UCSD) to conduct research on competitive interactions between the gut microbiome and the pathogen Salmonella typhimurium (STM). The project aims to use advanced metatranscriptomic and metatranslatomic sequencing techniques to gain insights into the metabolic profiles of STM and its...
This $828,820 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate the molecular mechanisms by which the commensal bacterium Enterococcus faecalis transitions from a gut resident to a pathogen that can breach the intestinal barrier and cause systemic infections. The key objectives are to: 1) define how E. faecalis disrupts endoplasmic reticulum (ER)...
This $479,730 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research to elucidate the mechanisms by which prophages (viruses integrated into bacterial genomes) modulate the production of the antimicrobial compound reuterin in the probiotic gut bacterium Limosilactobacillus reuteri. The research aims to: 1) characterize the interplay between a prophage-derived protein...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research to investigate the mechanisms by which the gut microbiota, specifically short-chain fatty acids, inhibit the growth of the enteric pathogen Yersinia enterocolitica. The $195,213 award, spanning from November 2024 to October 2026, will fund in vitro studies and mouse model experiments to elucidate how Yersinia enterocolitica can overcome this "colonization resistance" from the gut microbiota. The research aims to reveal novel molecular mechanisms of short-chain fatty acid toxicity and bacterial resistance, which could have broader implications for understanding how the gut microbiome provides protection against enteric pathogens.

Generated 7/1/25, 1:51 AM