This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research to investigate the mechanisms by which the gut microbiota, specifically short-chain fatty acids, inhibit the growth of the enteric pathogen Yersinia enterocolitica. The $195,213 award, spanning from November 2024 to October 2026, will fund in vitro studies and mouse model experiments to elucidate how Yersinia enterocolitica can overcome this "colonization resistance" from the gut microbiota. The research aims to reveal novel molecular mechanisms of short-chain fatty acid toxicity and bacterial resistance, which could have broader implications for understanding how the gut microbiome provides protection against enteric pathogens.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $195.2k | 11/8/24 |