Project Grant R01AI187756

Award Date 12/1/24
Completion Date 11/30/29
Dollars Obligated $480K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Madison, WI 53706, USA
Similar Awards
The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $560,178 Project Grant to the University of Wisconsin - Madison. The goal of this 5-year grant, which runs from Jul 25, 2025 to Jun 30, 2030, is to understand the dynamics of the interaction between Staphylococcus aureus bacteriophages, the bacteria, and the mammalian host. Specifically, the research aims to elucidate the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $427,625 to the University of Wisconsin-Madison to develop an innovative approach for producing recombinant therapeutic proteins in probiotic bacteria. The goal is to create a dietary sugar-regulated system for expressing proteins like interleukin-22 in the gastrointestinal tract, without relying on antibiotic...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $369,431 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Wisconsin-Eau Claire. The grant, awarded on August 21, 2024, supports a project titled "Molecular Determinants and Behavioral Fingerprints of Schistosome Miracidia Host-Seeking". The project aims to quantitatively describe the host-seeking behaviors of schistosome miracidia, the aquatic larval...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $173,030 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to President and Fellows of Harvard College. The grant, awarded on September 25, 2024, will fund the development of a novel assay for targeted isolation of environmental bacteriophages (phages) based on their receptor dependencies. The project aims to create a generalizable technique that allows selecting phages that require...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $229,411 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to Northwestern University to investigate Neisseria gonorrhoeae double-stranded bacteriophage. The research aims to determine whether one or more phage islands can produce phage, explore the regulation of two essential LexA orthologs, and assess whether these phage(s) can infect Neisseria strains or species. This project builds upon the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $224,807 to the University of California, Irvine (UCI) to conduct research on identifying and engineering microbial enzymes that can modulate peptidoglycan (PG) metabolite levels in the gut. The key objectives are to: 1) use chemoproteomic methods to discover highly active, secreted, and stable PG-degrading enzymes...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $267,310 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Illinois in Chicago. The grant, awarded on August 27, 2024, supports research to evaluate the role of a lipoic acid transfer protein in Staphylococcus aureus metabolism and virulence. The project aims to determine how this lipoic acid transfer protein interfaces with other metabolic enzymes to control...
This Project Grant award of $106,446 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Program (CFDA 93.855) aims to establish an innovative, high-throughput method for identifying bacteriophages (phages) and their bacterial host cells within complex microbial communities like the human gut microbiome. The principal investigator will adapt a single-cell RNA sequencing (scRNA-seq) protocol to rapidly screen bacterial cells...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $182,084 to the University of Wisconsin - Madison to investigate the role of prostaglandin E2 in Listeria monocytogenes-induced CD8+ T-cell priming. The research aims to identify bacterial determinants of PGE2 induction, define the signaling pathways and cell types upon which PGE2 acts to promote CD8+...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $661,693 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to The University of Iowa. The grant, awarded on June 16, 2025, supports research to define the structure and function of a new family of peptidoglycan crosslinking enzymes found in Clostridioides difficile, an opportunistic pathogen and leading cause of hospital-acquired infectious diarrhea. The research aims to advance...

The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $479,730 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Wisconsin - Madison. The 5-year grant, effective from December 1, 2024 to November 30, 2029, will support research to elucidate the mechanisms by which prophages (viral DNA) in the gut symbiont Limosilactobacilus reuteri modulate the production of the antimicrobial compound reuterin. The research aims to determine how this phage-mediated regulation of microbial metabolism impacts the probiotic effects of L. reuteri in the mammalian gut. The project leverages sophisticated genome editing tools to uncover fundamental knowledge on the interplay between prophages and probiotic gut symbionts, with the goal of driving a paradigm shift in understanding the role of prophages in promoting human health.

Generated 8/5/25, 5:15 AM