This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $1,144,714 to the University of Illinois to conduct research aimed at discovering novel antibiotics for gram-negative pathogens. The primary goals are to identify physicochemical traits that allow antibiotics to evade efflux pumps in E. coli, P. aeruginosa, and A. baumannii, and then apply this knowledge to develop at...
This federal Project Grant award of $195,213 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research by the University of California, Davis to investigate the mechanisms by which the gut microbiota, specifically short-chain fatty acids, can inhibit the growth of the enteric pathogen Yersinia enterocolitica. The research aims to elucidate the molecular mechanisms underlying Y. enterocolitica's sensitivity and...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is focused on elucidating the role of Akkermansia muciniphila in Group B Streptococcal (GBS) vaginal colonization and ascending infection. The $148,568 award will support research to investigate the specific mechanisms by which A. muciniphila promotes GBS interaction with human vaginal epithelial cells, potentially...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $891,678 to the Scripps Research Institute in La Jolla, CA to conduct research on how metabolites from the intestinal microbiota can modulate host immune responses. The researchers will employ chemical biology and proteomics methods to identify specific microbiota-associated bile acid protein targets in mammalian cells...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $220,340 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Carnegie Institution of Washington for the project "Coordinated Growth in Microbial Communities and Implications for Antibiotic Sensitivities". This research aims to understand how cross-phylum signals between Lactiplantibacillus plantarum and Acetobacter species affect cellular physiology and antibiotic...
This federal Project Grant award of $254,478 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to identify mechanisms of resistance to pathogen-specific antibacterial antisense compounds and develop strategies to overcome them. The award recipient, The University of Texas Southwestern Medical Center, will investigate resistance to these novel antibacterial compounds called...
This $926,057 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research is supporting research to understand how the gut microbiota influences immune responses, particularly B-cell development and antibody production, following vaccination. The project aims to identify gut stromal cell populations and microbial components that are crucial for enhancing stromal cell function and promoting improved...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $267,310 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Illinois in Chicago. The grant, awarded on August 27, 2024, supports research to evaluate the role of a lipoic acid transfer protein in Staphylococcus aureus metabolism and virulence. The project aims to determine how this lipoic acid transfer protein interfaces with other metabolic enzymes to control...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $479,730 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Wisconsin - Madison. The 5-year grant, effective from December 1, 2024 to November 30, 2029, will support research to elucidate the mechanisms by which prophages (viral DNA) in the gut symbiont Limosilactobacilus reuteri modulate the production of the antimicrobial compound reuterin. The research aims to...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $224,807 to the University of California, Irvine (UCI) to conduct research on identifying and engineering microbial enzymes that can modulate peptidoglycan (PG) metabolite levels in the gut. The key objectives are to: 1) use chemoproteomic methods to discover highly active, secreted, and stable PG-degrading enzymes...