Project Grant 2618765
- Federal Grant Award Summary The National Science Foundation's Division of Biological Infrastructure awarded $894,785 to the University of California, Merced under the Biological Sciences program (CFDA 47.074) to develop TOOLS4CELLS, an integrated experimental and computational platform for high-throughput discovery of protein-protein interactions (PPIs). The award, obligated on September 15, 2025, with completion expected by August 31, 2028, will deliver a novel platform that combines...
- Federal Project Grant Award Summary The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $800,000 Project Grant to the University of California, San Diego on June 15, 2026, for collaborative research on transcriptome-wide visualization and functional characterization of RNA tertiary structures in human cells. Under this award, funded through the Biological Sciences program (CFDA 47.074) with a completion date of May 31, 2029, the research team will...
- Summary of Federal Project Grant Award William Marsh Rice University received a $986,944 Project Grant from the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074), effective September 1, 2025 through August 31, 2028. The TOOLS4CELLS project will develop a safe, programmable self-replicating RNA (sRRNA) system for transient protein production in bacteria. Leveraging the replicative machinery of single-stranded RNA bacteriophages and incorporating regulatory...
- Federal Grant Award Summary The National Science Foundation's Division of Molecular and Cellular Biosciences awarded $350,000 under the Biological Sciences program (CFDA 47.074) to Trustees of Tufts College for the TOOLS4CELLS project, effective August 1, 2025, through July 31, 2026. This Project Grant supports the development of turn-on biosensors (TOBS)—a novel measurement technology enabling real-time detection of endogenous biomolecules in live cells. The primary deliverable is the...
- Federal Project Grant Award Summary The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded $1.2 million to the University of California, Davis under the Biological Sciences program (CFDA 47.074) on July 15, 2026, with a completion date of June 30, 2030. This Project Grant supports fundamental research into gene-specific nuclear messenger ribonucleoprotein (mRNP) assembly and quality control mechanisms. The research focuses on understanding how genetic...
- The National Science Foundation (NSF) awarded a $300,000 Project Grant under its Biological Sciences program (CFDA 47.074) to the Georgia TECH Research Corporation for the "TOOLS4CELLS: EAGER: A MOLECULAR PURSUIT FOR THE ENGRAM: MICROFLUIDIC TEMPORAL TRANSCRIPTOMICS FOR SINGLE CELL LEARNING" project. This 2-year effort aims to develop innovative microfluidic tools and workflows to investigate the role of non-coding RNA in learning and memory storage in single-celled organisms. Key...
- Federal Grant Award Summary The National Science Foundation (NSF) Division of Biological Infrastructure awarded $1.2 million to the University of California, San Diego under the Biological Sciences program (CFDA 47.074) to develop advanced computational tools for peptide sequencing analysis. Initiated November 1, 2025, and extending through October 31, 2029, this Project Grant funds the creation of novel algorithms and software designed to overcome current limitations in mass...
- Federal Project Grant Award Summary The National Science Foundation's Division of Molecular and Cellular Biosciences awarded $967,237 to the University of California, Santa Barbara on June 15, 2026, under the Biological Sciences program (CFDA 47.074) to investigate the mesoscale biophysics of Arginine-Glycine-Glycine (RGG)/RNA interactions. This four-year project, extending through May 31, 2030, will deliver fundamental research establishing quantitative physical principles governing how RGG...
- This National Science Foundation (NSF) Project Grant, awarded under the Biological Sciences program (CFDA 47.074), provides $750,000 to Stanford University to develop new technologies for studying RNA, the essential molecules that carry genetic information and play crucial roles in cell functions. The key products and services to be delivered under this 3-year award include: Creating non-destructive methods to directly study RNA localization and interactions within living cells, achieving...
- Federal Project Grant Award Summary Award Details: The National Science Foundation (NSF) Division of Integrative Organismal Systems awarded $447,488 to the Regents of the University of California at Riverside under the Biological Sciences program (CFDA 47.074), effective October 1, 2025, with completion targeted for December 31, 2026. This CAREER award, funded in part under the American Rescue Plan Act of 2021, supports mechanistic studies of cilium proteins in cell signaling. Research...
The National Science Foundation (NSF) Division of Biological Infrastructure awarded $1.0 million in Project Grant funding (CFDA 47.074, Biological Sciences program) to the Regents of the University of California at Riverside for the TOOLS4CELLS project, effective September 1, 2026, through August 31, 2029. This award supports the development and refinement of TimeCLIP technology, a biotechnological method designed to enable time-resolved detection of protein-RNA interactions by determining when interactions occur during an RNA molecule's lifetime, rather than providing only static snapshots as current methods do. The project delivers methodological advancements addressing two major technical barriers in the field: expanding TimeCLIP's applicability to RNA-binding proteins that crosslink inefficiently under standard conditions through evaluation of alternative photoactivatable ribonucleosides and ultraviolet wavelengths, and adapting the technology for double-stranded RNA-binding proteins and protein-associated RNA hybrids through integrated time-resolved metabolic labeling and computational analysis. Broader impact activities include graduate and postdoctoral training in RNA biology, genomics, quantitative analysis, and responsible research practices, alongside dissemination of protocols and benchmark datasets to the scientific community to advance gene regulation and cellular function research with applications to human health.Federal Project Grant Summary