Project Grant 2622018
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded Emory University a $724,356 Project Grant under the Biological Sciences program (CFDA 47.074) to investigate the role of the protein ARL13B in controlling ciliary cyclic AMP (cAMP) signaling. The research aims to unravel the ciliary cAMP "signature", optogenetically stimulate cAMP signaling within normal and ARL13B-excluded cilia, investigate the role of ciliary cAMP signaling in remodeling...
- Federal Project Grant Award Summary The National Science Foundation's Division of Molecular and Cellular Biosciences awarded a $1.644M CAREER grant (CFDA 47.074, Biological Sciences program) to the University of California, Davis for the five-year period from June 1, 2026 through May 31, 2031. This project grant supports fundamental research investigating the cellular and molecular mechanisms underlying proprioceptor maturation, with specific focus on how changes in sodium channel function and...
- This Project Grant awarded by the National Science Foundation (NSF) Biological Sciences Program (CFDA 47.074) will support research to investigate the biochemical mechanisms that regulate receptor tyrosine kinase (RTK) proteins and their impact on the development of brain circuits controlling social and emotional behaviors. The $600,000 award, spanning 2025-2027, will be conducted by Children's Hospital Los Angeles, a prominent pediatric academic medical center and research institution. The...
- Federal Project Grant Award Summary The University of California, Santa Barbara received a $1,201,130 CAREER grant award from the National Science Foundation's Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074) to investigate the mechanisms of peroxisomal membrane protein biogenesis. The research, which commenced June 1, 2026 and extends through May 31, 2031, will advance understanding of how cells synthesize, target, and maintain proteins within...
- This $1.5 million Project Grant from the National Science Foundation (NSF), under the Engineering federal grant program (CFDA 47.041), will fund research at the University of California Irvine from October 2022 through September 2026. The university will develop hydrogel-based bioengineering technologies to reproducibly generate distinct spatial organization and cellular diversity within cortical organoids, mimicking the development of different brain regions. Researchers will leverage expertise...
- This $526,873 federal Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research at the University of California, Riverside on the mechanisms of protein-protein associations facilitated by molecular "glues". The research aims to computationally model and experimentally investigate how these molecular glues mediate the formation of protein complexes and enhance their biological functions. The project will contribute to...
- The Regents of the University of California at Riverside received a $1.56M Project Grant award from the National Science Foundation Division of Integrative Organismal Systems. The award is part of the NSF's Biological Sciences program (CFDA 47.074) and will fund research from September 2021 through August 2025 to decipher the robustness mechanisms of the stem promoting transcription factor gradient. The Biological Sciences program aims to advance the field and strengthen the national...
- This $899,809 project grant from the National Science Foundation Division of Integrative Organismal Systems, under the Biological Sciences program (CFDA 47.074), will fund research to elucidate the molecular and cellular mechanisms governing ciliate-algal symbiosis. The grantee, Regents of the University of California at Riverside, will utilize a single-celled ciliate model to identify genotype-phenotype relationships and discover novel genes governing endosymbiosis with dinoflagellate algae....
- This $497,856 Project Grant from the National Science Foundation Division of Integrative Organismal Systems under the Biological Sciences federal grant program (CFDA 47.074) will fund research at the University of California, Riverside to elucidate the molecular and cellular mechanisms governing ciliate-algal symbiosis. The research aims to discover and characterize genes involved in the symbiotic relationship between ciliates and dinoflagellate algae, with the goal of developing strategies to...
- Federal Project Grant Award Summary The University of California, San Diego received a $700,000 Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074), effective August 1, 2025, through July 31, 2028. This award funds fundamental research to elucidate the molecular mechanisms of riboswitch-based gene regulation in manganese ion transporters. The project will map the co-transcriptional folding...
CAREER: Mechanistic Studies of Cilium Proteins in Cell Signaling The University of California at Riverside received a $447,488 Project Grant award from the National Science Foundation's Division of Integrative Organismal Systems under the Biological Sciences program (CFDA 47.074), effective October 1, 2025, with completion targeted for December 31, 2026. This award, partially funded under the American Rescue Plan Act of 2021, supports fundamental research to identify and characterize the full catalog of receptor proteins located in primary cilia of neural progenitor cells. The research employs novel biotin-labeling techniques combined with mass spectrometry analysis to map ciliary proteins and decipher the mechanisms by which these proteins influence developmental decisions during brain formation. The project will generate comprehensive research outputs including a complete protein inventory of primary ciliary receptors in neural progenitor cells, mechanistic insights into how these proteins regulate brain development, and peer-reviewed scientific publications advancing understanding of cilium-mediated cell signaling. Additionally, the award supports an educational component engaging local K-12 students and high school teachers in laboratory research to promote sustained interest in the biological sciences. Results from this work will enhance understanding of normal brain development and provide insights relevant to addressing brain developmental disorders associated with ciliary signaling mutations.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $447.5k | 3/23/26 |