Project Grant 2446451
- This $3,000,000 project grant, awarded by the National Science Foundation (NSF) under the Engineering (CFDA 47.041) program, aims to solve the long-standing challenge of developing self-amplifying ribonucleic acid (SARNA) technologies. The project, led by Trustees of Boston University, a private non-profit research university, will: Synthesize a diverse library of modified nucleoside triphosphates (ModNTPs) and use them to produce modified SARNA with extended cellular half-life. Evaluate the...
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) federal project grant award to William Marsh Rice University provides $1,199,994 to study the role of bacterial deaminase toxins in cell physiology and microbial interactions. The project aims to characterize the substrate preference and structure of these DNA-targeting toxins, explore their biological roles, and develop tools to track toxin-mediated interactions in microbial communities. This research will enhance...
- The National Science Foundation (NSF) awarded a $623,295 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to William Marsh Rice University in Houston, TX. The purpose of this 3-year grant, with an award date of August 1, 2025, is to develop new methods for isolating, studying, and utilizing a wider variety of DNA plasmids as tools to program microbes for beneficial purposes. The research aims to expand the current limited plasmid toolbox from a few to potentially...
- This $849,713 Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research to elucidate RNA-RNA interaction networks during interbacterial interactions involving the bacterium Pseudomonas aeruginosa. The research team at Boston Children's Hospital seeks to define the small RNA (sRNA) interaction network in P. aeruginosa and decode the regulatory roles played by sRNAs during its interactions with other bacteria. The project will...
- William Marsh Rice University was awarded a three-year, $673,890 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences under the Biological Sciences (CFDA 47.074) federal grant program. The grant funds the SENTINELS project to develop a plug-and-play RNA sensing technology platform for surveillance and response capabilities against emerging viral diseases. The platform will allow researchers to rapidly incorporate new RNA sensors to detect unknown...
- This $299,779 National Science Foundation project grant under the Biological Sciences program (CFDA 47.074) funds research at Louisiana State University from August 2022 to July 2024 to design an RNA-based dual regulator for repetitive gene expression regulation. The research integrates biological experiments and computational studies to train scientists and engineers in interdisciplinary research. It also aims to cultivate a multidisciplinary perspective for problem-solving. Specifically, the...
- The National Science Foundation (NSF) awarded a $919,999 Project Grant under the Biological Sciences program (CFDA 47.074) to the Regents of the University of California at Riverside. This 3-year grant, beginning September 1, 2023, supports research to investigate the evolution and functional role of small regulatory RNAs (sRNAs) in diverse bacterial lineages, particularly those living symbiotically within pest insect hosts. The project aims to determine how sRNA sequence divergence and...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded Rice University a $373,174 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to conduct research toward developing lifelike synthetic cells through engineered control of DNA replication from August 15, 2021 to July 31, 2024. The Biological Sciences program aims to advance biological knowledge and understanding of major problems to strengthen the nation's scientific enterprise....
- The National Institute of General Medical Sciences (NIGMS) awarded Lynntech Inc. a $283,304 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to develop software that optimizes the replication of self-amplifying RNA (saRNA) for use in vaccines and therapeutics. The goal is to create machine learning-based software that can enhance the replicability of saRNA, which can increase the duration of protein expression from saRNA cargo compared to conventional mRNA....
- This $199,997 federal Project Grant, awarded by the National Science Foundation's Engineering program (CFDA 47.041), aims to improve the stability and sensitivity of a heat-resistant version of the CRISPR-Cas13 enzyme for rapid and accurate detection of disease-causing RNA. The collaborative research project between William Marsh Rice University and its partners will leverage mechanism-based protein engineering and electrochemical devices to generate next-generation RNA detection tools for...
The National Science Foundation's Biological Sciences Federal Grant Program (CFDA 47.074) awarded $986,944 to William Marsh Rice University to develop a self-amplifying RNA (saRNA) system for bacterial protein synthesis. The project, titled "TOOLS4CELLS: Development of Self-Amplifying RNA Systems for Bacterial Protein Synthesis," aims to engineer a versatile saRNA platform that enables precise, short-term protein production in a broad range of bacterial species without the risks of horizontal gene transfer or permanent genomic integration. The technology has applications in environmental remediation, sustainable agriculture, and therapeutic delivery by enabling temporary, task-specific microbial functions with improved biosafety. The project will contribute to global efforts in environmental sustainability, food security, and public health through partnerships with academic institutions, industry, and non-profit organizations. The award period is from September 1, 2025, to August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $986.9k | 9/3/25 |