Project Grant 2503218
- The National Science Foundation (NSF) awarded a $955,876 Project Grant to Northwestern University to investigate the role of prion-mediated epigenetic regulation in the budding yeast, Saccharomyces cerevisiae. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to examine how two different yeast prions, [SWI+] and [MOT3+], interact and impact global transcription and protein homeostasis. Using advanced multi-omics techniques, the research program will identify...
- The National Science Foundation (NSF) awarded a Project Grant under the Biological Sciences (CFDA 47.074) program to The Johns Hopkins University totaling $856,135. The award will fund research to develop and apply new single-molecule methods to measure protein production in individual live cells, rather than population averages. The goal is to better understand the regulatory mechanisms governing when and where protein production occurs in cells. In addition to the core research, the project...
- This $316,968 federal Project Grant was awarded on June 1, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports fundamental scientific research and advanced training focused on understanding the regulation, inhibition, and quality control mechanisms of ribosomes, which are the cellular machinery responsible for protein synthesis. The key research areas include translation fidelity,...
- The National Science Foundation (NSF), through its Mathematical and Physical Sciences program (CFDA 47.049), has awarded a $749,999 Project Grant to Princeton University and San Diego State University. The grant will fund the development of a novel method for tracking the synthesis, localization, and dynamics of RNA messages in living cells using metabolically incorporated fluorescent nucleosides. This innovative approach will enable researchers to study the organization of cellular structures...
- This $474,385 National Science Foundation Office of Integrative Activities Project Grant will fund research at Southern University and A&M College from July 2022 through June 2025 to elucidate conserved eukaryotic nucleolar and ribosomal stress mechanisms. The research aims to identify common pathways that link cell growth to the cell cycle and subsequent stress responses when growth is arrested in unicellular and multicellular eukaryotes. The researchers will systematically express and...
- The National Science Foundation (NSF) Division of Integrative Organismal Systems awarded a $299,983 Project Grant to North Carolina State University (NCSU) under the agency's Biological Sciences program (CFDA 47.074). The objective of this 2-year grant is to develop a new biotechnology called RIBOPI that will enable efficient, scalable, and cost-effective quantification of gene-specific translation regulation. RIBOPI aims to make translation regulation analysis as accessible as RNA sequencing...
- The National Science Foundation (NSF) awarded a $299,529 Project Grant to the University of California, San Diego (UCSD) under the Biological Sciences program (CFDA 47.074) to develop novel "LOC-SEQ" technologies for genome-wide screening of factors affecting mRNA localization. This research aims to bridge the gap between identifying spatially localized RNAs and understanding the mechanisms directing their localization, initially focusing on mitochondrial localization in yeast and...
- This $592,495 Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074) will support research at Dartmouth College from February 15, 2023 to January 31, 2025. The project aims to identify the molecular pathway controlling meiotic termination in budding yeast through experiments analyzing how autophagy shapes the meiotic transcriptome and proteome at different stages of meiosis. Researchers will define...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $949,953 Project Grant to the Research Foundation Of The City University Of New York, doing business as Rfcuny - Hunter College, from August 1, 2023 to July 31, 2026. The grant, funded under the Biological Sciences program (CFDA 47.074), will support research to identify molecular interactions and build a detailed model of translational regulation, specifically examining the role of eIF3 and 4E-BP in...
- This federal Project Grant award for $678,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand the molecular mechanisms governing the assembly of eukaryotic ribosomes. The research aims to define the co-transcriptional assembly events and transitions towards stable post-transcriptional nucleolar assembly intermediates of ribosomal subunits, leveraging advanced...
The National Science Foundation (NSF) has awarded a $741,544 Project Grant under the Biological Sciences program (CFDA 47.074) to investigate how dormant yeast cells reorganize their cellular machinery, particularly the ribosomes that produce proteins. The principal investigators, Dr. Ahmad Jomaa at the University of Virginia and Dr. Simone Mattei at the EMBL Imaging Center in Germany, will use advanced imaging and molecular biology techniques to understand how ribosomes become inactive by attaching to fragmented mitochondria in dormant cells. This research aims to provide fundamental insights into how cells adapt to extreme environmental conditions, with potential implications for medicine, agriculture, and biotechnology. The project also includes an educational outreach effort called "Molecular Touch" that will introduce middle and high school students to structural biology using 3D-printed ribosome models. The award period is from August 1, 2025 to July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $741.5k | 7/29/25 |