The National Science Foundation (NSF) awarded a $955,876 Project Grant to Northwestern University to investigate the role of prion-mediated epigenetic regulation in the budding yeast, Saccharomyces cerevisiae. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to examine how two different yeast prions, [SWI+] and [MOT3+], interact and impact global transcription and protein homeostasis. Using advanced multi-omics techniques, the research program will identify...
This $638,454 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research at Dartmouth College to define the functions of an essential, conserved mitochondrial protein that links the organelle's matrix to the cytoplasm. Over three years, the researchers will investigate how specific mitochondrial components integrate mitochondrial function within plant cells, focusing on the roles of ATAD3 proteins that span the inner and outer...
This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award provides $240,000 in funding from July 1, 2024 to June 30, 2027 to support a postdoctoral research fellowship investigating the molecular mechanisms that enable adaptation of Saccharomyces cerevisiae yeast populations to complex environmental stressors. The research aims to reveal evolutionary dynamics resulting from varying levels of environmental complexity, with the goal of improving...
This $317,533 federal Project Grant awarded by the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) aims to develop a mathematical model that can explain the heterogeneity in how yeast cells transition between proliferation and quiescence in response to various stress stimuli. The award to North Carolina State University will leverage novel deep learning techniques to directly learn differential equation models from single-cell protein expression data....
This $414,390 National Science Foundation project grant supports research at Eastern Michigan University to advance understanding of autophagy, a cellular recycling and protection process. Funded under the NSF Biological Sciences program (CFDA 47.074), the three-year award beginning in February 2023 will investigate the molecular mechanisms that drive formation of the autophagosome, a vesicle that degrades cellular cargo. Researchers will study proteins involved in conjugating the ATG8 protein...
This $452,399 federal Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at Hofstra University to investigate the epigenetic regulation of transposable elements in maize. The research aims to study the RNA-directed DNA methylation (RDDM) induced by naturally occurring maize "killer" alleles and explore the dynamic regulation of transposable element silencing in response to developmental cues. The project will...
This National Science Foundation (NSF) Project Grant, under the Biological Sciences program (CFDA 47.074), was awarded to Stetson University, Inc. in the amount of $502,998 with a period of performance from August 1, 2023 to July 31, 2026. The project aims to investigate the molecular mechanisms of fungal cell fusion, using the yeast Saccharomyces cerevisiae as a model system. Specifically, the research will focus on identifying novel regulators of cell wall degradation and plasma membrane...
This National Science Foundation Project Grant of $673,524 supports research at North Carolina State University to develop a mathematical model of mitosis through the Biological Sciences program (CFDA 47.074). The model will simulate chromosome segregation and nuclear envelope shape change coordination in fission yeast mitosis. Researchers will extend an existing mitosis model to include a deformable elastic nuclear envelope integrating the spindle, chromosomes, and nuclear envelope. They will...
The National Science Foundation Division of Molecular and Cellular Biosciences awarded a $293,514 Project Grant to The Trustees of Trinity College in Hartford, Connecticut. The grant supports research from September 1, 2021 to August 31, 2024 under the Biological Sciences program (CFDA 47.074). The grant funds development of microelectrophoretic and statistical tools to study kinase- and reactive oxygen species-based signaling pathways in the social amoeba Dictyostelium discoideum. The...
This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) was provided to Brandeis University to conduct research investigating the role of heterochromatin and the protein HP1 in maintaining epigenetic memory and gene expression patterns in cells. Specifically, the $229,840 award will fund research to: (1) engineer synthetic H3K9me binding modules to test how DNA compartmentalization influences epigenetic memory, (2) determine how...