Project Grant R35GM156426
Award Date
4/17/25
Completion Date
3/31/30
Dollars Obligated
$678K
Federal Agency
National Institute of General Medical Sciences
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
New York, USA
Similar Awards
This $392,500 project grant awarded by the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to mechanistically characterize the enzymology of human ribosome biogenesis. The research aims to fill a key knowledge gap in understanding the molecular mechanisms underlying ribosome biogenesis, a highly energy-intensive process that is dysregulated in diseases known as ribosomopathies and upregulated in cancers....
This federal Project Grant award in the amount of $463,083, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research at Rowan University to define the mechanisms of ribosome assembly within mitochondria. The key objectives of this 3-year research project are to: 1) determine the composition and binding characteristics of protein preassembly complexes involved in mitochondrial ribosome...
The National Institute of General Medical Sciences (NIGMS) awarded a $375,988 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Rockefeller University to investigate the structural dynamics and function of the nuclear pore complex (NPC) in facilitating the transport of large cellular cargoes. The research aims to elucidate the mechanisms by which the NPC, a large protein complex that regulates molecular trafficking across the nuclear envelope, can accommodate and...
The National Institute of General Medical Sciences (NIGMS), through its Biomedical Research and Research Training program (CFDA 93.859), awarded a $355,584 Project Grant to the New Mexico Institute of Mining and Technology (New Mexico Tech) on August 18, 2023. This funding will support research to determine the biochemical basis and functional implications of the interaction between the proteins XRN2 and DDX23, and explore their cooperative role in regulating RNA-DNA hybrid structures...
The National Institute of General Medical Sciences (NIGMS) awarded a $385,000 Project Grant (CFDA 93.859, Biomedical Research and Research Training program) to the University of Rochester to develop new supramolecular strategies to modulate biomolecular folding and assembly. The research aims to: Develop supramolecular mimics of natural chaperones to inhibit protein misfolding and induce protein refolding, establishing structure-function relationships and using photoswitches to dynamically...
The National Institute of General Medical Sciences (NIGMS) awarded Vanderbilt University a $396,250 Project Grant under the NIGMS Biomedical Research and Research Training Program (CFDA 93.859) to conduct research on the regulation and function of biomolecular condensates. The 5-year project aims to define the core biochemical principles that underpin the spatial and temporal regulation of biomolecular condensates, using the P granule model condensate in C. elegans embryogenesis. Key goals...
The National Institute of General Medical Sciences (NIGMS) awarded a $313,520 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the Regents of the University of Michigan. The objective of this 5-year grant, with a start date of September 21, 2024, is to develop a suite of novel live-cell chemical probing technologies based on the RNP-MAP (RNA-Protein Networks Analyzed by Mutational Profiling) approach. This work aims to enhance the RNP-MAP framework to create new methods...
This federal Project Grant award, valued at $382,801 and awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), aims to develop a new class of artificial RNA-based condensates as customizable organelles for use in living cells. The key objectives are: Optimizing the sequence and structure of RNA "nanostars" to produce condensates with tailored thermodynamic and biophysical properties, as well as...
This $372,880 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training Program supports research to understand how cells regulate protein synthesis in response to environmental stressors. The project aims to investigate three key areas: 1) the coordination of eIF2 translation initiation factor complex formation, 2) the mechanisms by which eIF2 selects or disregards mRNAs for translation during the integrated...
The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Molecular Instruments, Inc., a for-profit manufacturer of scientific instruments, in the amount of $905,853. The funding will support the company's research and development of advanced technologies for automated, ultrasensitive, and multiplex imaging of RNA and proteins in biological samples. Specifically, the project aims to engineer...