Project Grant 2515793
- The National Science Foundation (NSF) awarded a Project Grant under the Biological Sciences (CFDA 47.074) program to The Johns Hopkins University totaling $856,135. The award will fund research to develop and apply new single-molecule methods to measure protein production in individual live cells, rather than population averages. The goal is to better understand the regulatory mechanisms governing when and where protein production occurs in cells. In addition to the core research, the project...
- The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program awarded a $1,050,000 Project Grant to Princeton University to deepen the understanding of chemical modifications on ribonucleic acid (RNA) and their role in biological processes. The 3-year project, titled "Illuminating the Dihydrouridine Epitranscriptome," aims to characterize the RNA modification dihydrouridine (D) and its writer enzymes, as well as elucidate their biological function...
- This $605,020 Project Grant awarded by the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports research conducted by Professor Byron Purse of the Department of Chemistry and Biochemistry at San Diego State University. The research aims to determine how molecular structure and local environment influence key properties of fluorescent nucleobase analogues (FBAs), which are synthetic molecules that mimic natural genetic bases and enable sensitive...
- The National Science Foundation (NSF) Division of Chemistry awarded a $460,000 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to Drs. Harish Vashisth from the University of New Hampshire and Esteban A Orellana Vinueza from Dartmouth College. The 3-year grant, effective September 1, 2025, supports collaborative research to study how chemical modifications to transfer RNA (tRNA) bases affect the structure, folding, and dynamics of tRNA isodecoders, which are...
- The National Science Foundation (NSF) awarded a $299,529 Project Grant to the University of California, San Diego (UCSD) under the Biological Sciences program (CFDA 47.074) to develop novel "LOC-SEQ" technologies for genome-wide screening of factors affecting mRNA localization. This research aims to bridge the gap between identifying spatially localized RNAs and understanding the mechanisms directing their localization, initially focusing on mitochondrial localization in yeast and...
- The National Science Foundation (NSF) awarded a $401,490 Project Grant under the Engineering program (CFDA 47.041) to the University of Massachusetts (UMass) to develop a modular toolset for imaging cellular metabolites using fluorogenic RNA riboswitches. The project aims to engineer fluorescent probes that can selectively detect and measure key metabolites, such as sugars and fatty acids, within living cells in real-time. This novel approach will enhance research in human health, nutrition,...
- The National Science Foundation (NSF) awarded a $630,000 Project Grant under the Biological Sciences (CFDA 47.074) federal grant program to the University of New Mexico (UNM) to develop an advanced optical microscopy system. The project aims to significantly improve the study of protein clustering and interactions on cell membranes, which could advance the understanding of cell signaling and related diseases like cancer. The highly interdisciplinary research will combine the MINFLUX and modal...
- San Diego State University Foundation was awarded a $495,940 project grant from the National Science Foundation Division of Chemistry under the Mathematical and Physical Sciences federal grant program (CFDA 47.049). The grant will support research to develop fluorescent nucleosides and oligonucleotides with new capabilities from August 1, 2021 through July 31, 2024. The funding will allow researchers at San Diego State University to advance the store of scientific knowledge and enhance...
- The National Science Foundation (NSF) awarded a $600,000 project grant under the Mathematical and Physical Sciences program (CFDA 47.049) to the Research Foundation of the City University of New York (RFCUNY) to support Professor Mahesh Lakshman's research on developing novel chemical methods for modifying nucleosides. Nucleosides are the fundamental building blocks of DNA and RNA, and this research aims to obtain a better understanding of chemical processes to enable selective modifications...
- This National Science Foundation (NSF) Project Grant, awarded under the Biological Sciences program (CFDA 47.074), provides $750,000 to Stanford University to develop new technologies for studying RNA, the essential molecules that carry genetic information and play crucial roles in cell functions. The key products and services to be delivered under this 3-year award include: Creating non-destructive methods to directly study RNA localization and interactions within living cells, achieving...
The National Science Foundation (NSF), through its Mathematical and Physical Sciences program (CFDA 47.049), has awarded a $749,999 Project Grant to Princeton University and San Diego State University. The grant will fund the development of a novel method for tracking the synthesis, localization, and dynamics of RNA messages in living cells using metabolically incorporated fluorescent nucleosides. This innovative approach will enable researchers to study the organization of cellular structures and how they respond to environmental stimuli, providing new insights into biological and biotechnological processes. The project will also provide interdisciplinary training to graduate students and postdoctoral fellows in areas such as organic synthesis, chemical biology, and cellular microscopy. The award period is from September 1, 2025, to August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $750.0k | 8/20/25 |