Project Grant 2332782

Award Date 4/1/24
Completion Date 3/31/27
Dollars Obligated $956K
Federal Grant Program
47.074
Assistance Type
Project Grant
Place of Performance
Chicago, IL 60611, USA
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This Project Grant award from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program is funding research at the Research Foundation of the City University of New York (RFCUNY), Brooklyn College, to elucidate the epigenetic mechanisms through which prions contribute to cellular adaptation in yeast. The $700,000 project, running from August 2024 to July 2027, aims to: (1) map changes in histone modifications associated with the [PIN+] prion; (2) determine the levels,...
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The National Science Foundation (NSF) awarded a $955,876 Project Grant to Northwestern University to investigate the role of prion-mediated epigenetic regulation in the budding yeast, Saccharomyces cerevisiae. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to examine how two different yeast prions, [SWI+] and [MOT3+], interact and impact global transcription and protein homeostasis. Using advanced multi-omics techniques, the research program will identify prion-specific changes in transcriptome, genomic occupancies, and proteomics. The results are expected to provide valuable insights into prion biology and its effects on yeast cell biology. This award also supports the training of graduate students and summer undergraduate interns, as well as an outreach program to engage underrepresented high school students in the Chicago area with the research. The project period runs from April 1, 2024, to March 31, 2027.

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