Project Grant 2501395
- The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program awarded a $987,578 project grant to The Johns Hopkins University with a project period from July 1, 2025 to June 30, 2028. The research project seeks to obtain quantitative information about the signaling properties of a member of the receptor tyrosine kinase family in response to different ligands. Highly quantitative biophysical methods will be used to understand how diverse extracellular signals...
- The National Science Foundation (NSF) awarded a Project Grant under the Biological Sciences (CFDA 47.074) program to The Johns Hopkins University totaling $856,135. The award will fund research to develop and apply new single-molecule methods to measure protein production in individual live cells, rather than population averages. The goal is to better understand the regulatory mechanisms governing when and where protein production occurs in cells. In addition to the core research, the project...
- The National Science Foundation (NSF) awarded a Project Grant of $419,168 under the Biological Sciences (CFDA 47.074) federal grant program to Duke University. This collaborative research project will study the multiscale mechanics of septin assembly and curvature sensing in biological cells. The research aims to determine how cells can sense micron-scale geometry using nanometer-scale septin proteins. The project will examine septin assembly across three scales - individual septin molecules,...
- This federal Project Grant award, provided by the National Science Foundation (NSF) through its Biological Sciences program (CFDA 47.074), supports fundamental research on the periplasmic chaperone network in bacterial cell surface formation. The $1,320,970 award to The Johns Hopkins University will investigate the physical principles and mechanisms governing this essential cellular process in bacteria, one of the most abundant forms of life on Earth. The multi-scale research approach will...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded a $992,128 project grant to The Johns Hopkins University from May 2021 through April 2024 under the Biological Sciences program (CFDA 47.074). The grant will fund research into the scope of collateral fitness effects and their mechanisms. The Biological Sciences program aims to promote advancement in the biological sciences and strengthen the national scientific enterprise through increasing knowledge and...
- This Project Grant award of $891,897 from the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program supports a collaborative research effort to study the multiscale mechanics of septin assembly and curvature sensing in biological cells. The research, conducted by the University of North Carolina at Chapel Hill (UNC-CH), aims to determine how cells can sense micron-scale geometry using nanometer-scale septin proteins. Key objectives include investigating...
- This federal Project Grant award of $946,895 from the National Science Foundation's (NSF) Division of Molecular and Cellular Biosciences (CFDA 47.074 Biological Sciences) will fund research to advance the understanding of protein phosphorylation and its role in coordinating cell division. The project aims to identify new enzymes that carry out phosphorylation and the substrate proteins they modify to ensure proper cell division. Researchers will employ computational, biochemical, proteomic,...
- This Project Grant award from the National Science Foundation's (NSF) Biological Sciences Federal Grant Program (CFDA 47.074) provides $493,916 to the Massachusetts Institute of Technology (MIT) to investigate how proteins and lipids coordinate the formation and function of membrane-associated condensates. The research aims to improve understanding of how the cell surface is organized, which could enable breakthroughs in biotechnology, disease treatment, and fundamental cell biology. The project...
- This $363,800 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research by The Johns Hopkins University investigating how supercoiled DNA impacts transcription, a core process of life that converts genetic information into RNA. The research will: Characterize how supercoiling affects transcription kinetics and correlation using in vitro single-molecule imaging of purified proteins and DNA constructs. Determine how chromosomal...
- This National Science Foundation (NSF) Biological Sciences program project grant, awarded to Oregon Health & Science University (OHSU), aims to uncover the underlying biophysical mechanisms of directed cell migration. The $1,049,497 grant, with a period of performance from January 2024 to December 2027, will examine how actin cytoskeletal networks and adhesion receptors interact as interdependent subsystems to facilitate matrix-guided cell migration, which is crucial for tissue formation and...
The National Science Foundation's Biological Sciences (CFDA 47.074) Federal Grant Program has awarded a $999,993.00 Project Grant to The Johns Hopkins University to investigate the assembly and regulation mechanisms of filamentous signaling platforms - large, supramolecular structures that play a key role in cellular signaling processes. The project aims to elucidate the structural, biochemical, and physical mechanisms by which these filamentous assemblies are formed and regulated. Specifically, the research will focus on: 1) determining how architectural complementarity dictates the interacting partners within a specific group of signaling filaments, 2) investigating the mechanical forces involved in assembling such filamentous structures on DNA, and 3) elucidating how different regulators target and inhibit specific signaling components in these pathways. The project will utilize computational methods, electron microscopy, single-molecule force measurements, and quantitative assays in both cell-free and cell-based systems. The grant period runs from August 1, 2025, to July 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.0m | 7/22/25 |