This $987,578 federal Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at The Johns Hopkins University to study the signaling properties of a family of receptor proteins known as receptor tyrosine kinases (RTKs). The key objectives are to: 1) Acquire comprehensive data on the potencies, efficacies, and preferences of different ligands (extracellular signaling molecules) in activating various biological responses of the epidermal growth factor receptor (EGFR), a member of the RTK family; 2) Perform a physical-chemical characterization of how EGFR self-associates in the cell membrane in response to its ligands; and 3) Uncover correlations between measurable physical parameters and signaling outcomes. The research aims to advance the fundamental understanding of how diverse extracellular signals are processed by this critical receptor to drive distinct cellular events. The 3-year project, commencing on July 1, 2025, will also provide training for graduate students in advanced microscopy techniques and enhance the educational experience of undergraduates, while conducting broader outreach activities to benefit young scientists.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $987.6k | 3/17/25 |