This $419,168 Project Grant, awarded by the National Science Foundation's (NSF) Division of Molecular and Cellular Biosciences under CFDA Program 47.074 Biological Sciences, supports a collaborative research project to study the multiscale mechanics of septin assembly and curvature sensing in biological cells. The project aims to develop a multiscale mechanical model of septin assembly and curvature sensing across three scales: the molecular scale, the filament scale, and the system scale. The...
This National Science Foundation Project Grant of $673,524 supports research at North Carolina State University to develop a mathematical model of mitosis through the Biological Sciences program (CFDA 47.074). The model will simulate chromosome segregation and nuclear envelope shape change coordination in fission yeast mitosis. Researchers will extend an existing mitosis model to include a deformable elastic nuclear envelope integrating the spindle, chromosomes, and nuclear envelope. They will...
This Project Grant award of $410,939 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports research at Clemson University to elucidate the biophysical mechanisms of membrane protein folding and stability. The project will use advanced single-molecule force spectroscopy techniques, such as atomic force microscopy, to probe how membrane proteins interact with cell membranes, maintain proper orientation, and achieve their final folded state during...
This $1,269,993 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research to understand the molecular basis of how plant cells establish the division plane during cell division. The project aims to dissect the function of cytoskeletal motor assemblies at the cortical division site and determine how they connect to molecules in the phragmoplast, the structure that forms the new cell wall during cytokinesis. Researchers at...
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049) provides $380,000 to Northeastern University to develop a new generation of computational models for studying eukaryotic cell motility. The research aims to better understand how cells move through complex tissues, which is critical for both healthy developmental processes and the spread of cancer. The project will involve a collaborative effort between...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program will provide $1,286,156 to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania, from September 1, 2024 to August 31, 2029. The grant will support advanced research on cytokinesis, the septin cytoskeleton, and their roles in fundamental cellular processes and disease...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $206,912 Project Grant under the Biological Sciences (CFDA 47.074) program to the University of North Carolina at Chapel Hill. The three-year grant, effective August 1, 2023 through July 31, 2026, supports collaborative research to enhance the understanding of protein structures and behaviors at extreme temperature and pressure conditions. The research aims to develop rules for predicting protein...
The National Science Foundation awarded a $538,838 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to The Regents of the University of California, San Francisco for research titled "Collaborative Research: Mapping Protein-Membrane Interactions from Molecules to Cell-Level Dynamics." The research will develop multiscale models to map how individual protein structures and compositions interact with and deform cell membranes at varying scales, from...
This $120,227 project grant awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program supports research at Northeastern University to develop a new theoretical approach for studying the three-dimensional architecture and conformational ensembles of genes and gene clusters. The project aims to: (i) model the mechanics of chromatin at the gene scale, (ii) investigate how genomic conformations are affected by factors like supercoiling and...
The National Science Foundation (NSF) awarded a $750,000 Project Grant under the Biological Sciences program (CFDA 47.074) to the University of North Carolina at Chapel Hill (UNC-CH) to study the effects of macromolecular crowding on protein stability and interactions. The 3-year project will develop and test a new model for explaining how crowded cellular environments impact the free energy, enthalpy, and entropy of protein and protein complex stability. Key activities include using 19F NMR...
This Project Grant award of $891,897 from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports a collaborative research project at the University of North Carolina at Chapel Hill (UNC-CH) to investigate the multiscale mechanics of septin assembly and curvature sensing in biological cells.
The key focus of the research is to develop a multiscale mechanical model of how septin, a cytoskeletal protein, can sense and respond to micron-scale curvatures on cell membranes despite its nano-scale size. The project will examine septin assembly across three scales - the molecular, filament, and whole-cell levels - to understand the relationships between septin's structure, organization, and curvature sensing abilities. The research combines simulation, modeling, and experimental methods to measure and analyze these multi-scale couplings. In addition to the scientific research, the project will also engage middle and high school students and teachers through educational activities on the theme of self-organization in biology.