This four-year Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences provides $885,852 to Oregon Health & Science University under the Biological Sciences program (CFDA 47.074) from August 2021 through July 2025. The funding supports quantitative exploration of molecular machine mechanisms to advance understanding of major challenges in biology. As the stated purpose of the Biological Sciences program is to promote progress in the field and...
The National Science Foundation Division of Molecular and Cellular Biosciences awarded Northeastern University a $100,000 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to support research on "The Biophysics of Collective Cell Locomotion" from December 15, 2021 through December 31, 2023. Through this funding, Northeastern University researchers in Boston, MA will investigate the major problem of understanding the biological sciences by examining the...
This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
This Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences Program (CFDA 47.049), focuses on developing a new generation of computational models to study eukaryotic cell motility, especially in complex geometries. The $380,000 award, granted to Northeastern University, supports a joint experiment-theory project to gain a quantitatively predictive understanding of cell motility processes, including how cells utilize "blebbing" and...
This Project Grant award, provided by the National Science Foundation's Engineering program (CFDA 47.041), will fund research at Wesleyan University to investigate the principles governing interactions at the interface between different groups of cells. The $199,982 award, effective July 1, 2025 through June 30, 2027, aims to advance the fundamental understanding of how cells from distinct tissues organize and interact when they come into contact, which is crucial for processes like tissue...
This Project Grant award, provided by the National Science Foundation's Mathematical and Physical Sciences (CFDA 47.049) program, supports collaborative research between Indiana University Indianapolis and Purdue University to develop a novel multi-scale 3D mathematical model to simulate cell migration. The $200,000 award will enable the researchers to integrate experimentally measured intracellular tension data into the model to better understand how external environmental factors, such as...
This National Science Foundation Project Grant of $492,743 will fund research into the impacts of intracellular and extracellular hydraulic environments on mammalian cell migration in confined spaces. Awarded on October 15, 2022 under the Engineering program (CFDA 47.041), the funding will support mathematical modeling to decipher the coupled effects of fluid interaction with cellular structures on cell behavior in confined migration. The awardee, the Research Foundation for the State University...
This National Science Foundation Project Grant of $419,750 will fund research at Washington University in St. Louis from August 1, 2022 to July 31, 2025 to study how living cells move across dissimilar physical environments and retain mechanical memories of prior environments. Specifically, the award will integrate experiments and computational modeling to examine how forces generated by cells modify their surroundings in two mechanically different environments during migration. This will reveal...
This two-year Project Grant from the National Science Foundation's Division of Biological Infrastructure, under the Biological Sciences program (CFDA 47.074), provides $138,000 to explore the biophysical mechanisms and genetics influencing dendritic cell migration. The fellow will determine how dendritic cells push, pull, and squeeze through tissues using tunable biomaterials and confocal microscopy. They will investigate how mechanical properties of tissues impact dendritic cell movement and...
This three-year $300,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences will support research into the molecular mechanisms governing cell membrane repair. Funded under the Biological Sciences program (CFDA 47.074), the grant aims to advance understanding of major problems in the biological sciences through basic research. Specifically, the principal investigator will conduct nonlinear surface spectroscopic investigations at Oregon State...