This Project Grant award of $891,897 from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports a collaborative research project at the University of North Carolina at Chapel Hill (UNC-CH) to investigate the multiscale mechanics of septin assembly and curvature sensing in biological cells. The key focus of the research is to develop a multiscale mechanical model of how septin, a cytoskeletal protein, can sense and respond to micron-scale curvatures on cell...
This National Science Foundation Project Grant of $673,524 supports research at North Carolina State University to develop a mathematical model of mitosis through the Biological Sciences program (CFDA 47.074). The model will simulate chromosome segregation and nuclear envelope shape change coordination in fission yeast mitosis. Researchers will extend an existing mitosis model to include a deformable elastic nuclear envelope integrating the spindle, chromosomes, and nuclear envelope. They will...
This $1,269,993 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research to understand the molecular basis of how plant cells establish the division plane during cell division. The project aims to dissect the function of cytoskeletal motor assemblies at the cortical division site and determine how they connect to molecules in the phragmoplast, the structure that forms the new cell wall during cytokinesis. Researchers at...
The National Science Foundation awarded a $367,636 Project Grant to the Massachusetts Institute of Technology from March 1, 2021 through February 29, 2024 under the Biological Sciences program (CFDA 47.074). The grant funds collaborative research on multidimensional single-cell phenotyping to elucidate relationships between genomes and phenotypes. The Biological Sciences program aims to advance biological knowledge and understanding of major problems through basic research. This award supports...
This federal Project Grant award of $946,895 from the National Science Foundation's (NSF) Division of Molecular and Cellular Biosciences (CFDA 47.074 Biological Sciences) will fund research to advance the understanding of protein phosphorylation and its role in coordinating cell division. The project aims to identify new enzymes that carry out phosphorylation and the substrate proteins they modify to ensure proper cell division. Researchers will employ computational, biochemical, proteomic,...
This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
This $750,000 Project Grant was awarded on April 15, 2025 by the National Science Foundation's (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences (CFDA 47.074) Federal Grant Program. The grant will fund research at the University at Albany, SUNY to develop manufacturable 3D mammalian cell culture systems focused on neural organoids with integrated sensing technologies. Key objectives include: (1) building and testing conformal microelectrode arrays to...
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049) provides $380,000 to Northeastern University to develop a new generation of computational models for studying eukaryotic cell motility. The research aims to better understand how cells move through complex tissues, which is critical for both healthy developmental processes and the spread of cancer. The project will involve a collaborative effort between...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences and Division of Mathematical Sciences awarded a $550,000 Project Grant under the Biological Sciences program (CFDA 47.074) to the University of Texas at Austin. The grant, titled "COLLABORATIVE RESEARCH: MODULUS: PROTEIN DROPLETS DRIVE MEMBRANE BENDING AND CYTOSKELETAL ORGANIZATION," seeks to improve understanding of how protein droplets interact with cellular membranes and the cytoskeleton. The...
This National Science Foundation (NSF) Project Grant under the Biological Sciences program (CFDA 47.074) provides $668,572 in funding to Northeastern University to conduct research on the molecular and biophysical mechanisms underlying contractile valve assembly and function. The research aims to characterize the inner structure and regulatory mechanisms of a donut-shaped contractile valve in the reproductive system of the nematode C. elegans, using advanced microscopy, genetic perturbations,...
This $419,168 Project Grant, awarded by the National Science Foundation's (NSF) Division of Molecular and Cellular Biosciences under CFDA Program 47.074 Biological Sciences, supports a collaborative research project to study the multiscale mechanics of septin assembly and curvature sensing in biological cells. The project aims to develop a multiscale mechanical model of septin assembly and curvature sensing across three scales: the molecular scale, the filament scale, and the system scale. The research combines simulation, modeling, and experimental methods to understand how cells can sense micron-scale curvatures using nano-scale septin proteins. No sub-awards are planned for this grant, which has an award date of August 1, 2025 and an ultimate completion date of July 31, 2029.