The National Science Foundation (NSF) awarded a $1,500,000 Project Grant under the Biological Sciences (CFDA 47.074) federal grant program to the University of Alabama at Birmingham (UAB). The grant, titled "Horizontal Gene Transfer at Landscape Scale in Microbial Communities Under Selection for Antimicrobial Resistance," will study the spread of antibiotic resistance genes in microbial communities and how this spread is affected by heavy metal pollution. The research will use a unique...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) project grant awarded to Baylor College of Medicine seeks to uncover the specific genes that confer antibiotic resistance in E. coli through a novel approach inspired by statistical physics. The $1,534,925 award spanning Aug 2024 to Jul 2027 will grow E. coli cultures and analyze the mutational ensemble using thermodynamic principles to predict the genes underlying antibiotic resistance. This technique aims to bridge...
This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $563,387.00 to the University of Mississippi to investigate the function of an unknown bacterial protein and its role in pilus biogenesis. The key products and services to be delivered include: Characterizing the function of the conserved protein BRESU_2828, which has been shown to interact with the global genetic regulator GcrA and impact pilus biosynthesis in the non-model...
This $597,945 federal Project Grant awarded by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) program supports research by Tobias W. Giessen at the University of Michigan, Ann Arbor to investigate the structure and function of peptide-modifying enzyme filaments found in bacteria and archaea. The proposed work will generate new insights into the self-assembly and catalytic activity of these filamentous enzymes, which...
This Project Grant award from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program provides $470,000 to the University of Pittsburgh to create a 3-year program that engages 18 high school and middle school science teachers in authentic microbiology research. The goal is to help teachers better understand how bacteria adaptively evolve in biofilms and incorporate these concepts into their classroom curriculum. The program will train teachers to lead experiments where...
The University of Michigan was awarded a $270,000 Project Grant from the National Science Foundation to support the project "Scalable Population Genetic and Phylogenetic Inference Using Large Samples of Microbial Data." The grant was awarded on April 1, 2021 with a completion date of March 31, 2024 under the NSF's Mathematical and Physical Sciences program (CFDA 47.049). The grant aims to advance understanding of major scientific problems by promoting progress in mathematical and...
This three-year National Science Foundation project grant of $140,899 will fund research into the impact of horizontal gene transfer on the evolution of antibiotic resistance in bacterial communities. The NSF Division of Environmental Biology awarded the grant on February 1, 2022 under the Biological Sciences program (CFDA 47.074) to investigate how plasmid-borne genes coding for beta-lactam antibiotic resistance evolve when transferred between Escherichia coli, Salmonella enterica, and...
This $303,254 Project Grant from the National Science Foundation's Division of Environmental Biology, under the Biological Sciences program (CFDA 47.074), will fund research exploring the idea that the earliest adaptive evolution occurred through self-amplifying cycles of chemical reactions, rather than nucleic acids. Over a three-year period from August 2022 to July 2025, Michigan State University will conduct theoretical and laboratory studies to analyze how mixtures of chemicals could...
The National Science Foundation (NSF) Division of Environmental Biology awarded a $229,210 EAGER (Early-concept Grants for Exploratory Research) project grant to the University of Mississippi. The grant titled "Surveying Impacts of Community Context on Adaptive Mutational Landscapes" will run from September 1, 2023 to August 31, 2025. The project aims to examine how community context alters species evolution using new techniques in whole-genome analyses. It will bridge the fields of...
This $592,188 Project Grant awarded by the National Science Foundation (NSF) under the Engineering program (CFDA 47.041) supports research by the Regents of the University of Michigan to investigate the genetics and biosynthesis of methanobactin, a novel compound produced by bacteria that binds to copper. The project aims to: (1) delineate the function of genes involved in methanobactin production, (2) engineer modified forms of methanobactin with potential for treating copper-related...