This three-year National Science Foundation project grant of $140,899 will fund research into the impact of horizontal gene transfer on the evolution of antibiotic resistance in bacterial communities. The NSF Division of Environmental Biology awarded the grant on February 1, 2022 under the Biological Sciences program (CFDA 47.074) to investigate how plasmid-borne genes coding for beta-lactam antibiotic resistance evolve when transferred between Escherichia coli, Salmonella enterica, and...
This National Science Foundation (NSF) Project Grant under the CFDA program "Biological Sciences" (47.074) is awarded to Trustees of Boston University to develop and optimize optogenetic tools for selecting bacterial cells based on dynamic, time-varying traits. The $796,158 award, effective August 1, 2023 through July 31, 2026, supports the researchers in creating light-inducible genetic constructs that trigger antibiotic resistance, enabling the isolation of bacteria exhibiting...
The National Science Foundation (NSF) Division of Environmental Biology awarded a $229,210 EAGER (Early-concept Grants for Exploratory Research) project grant to the University of Mississippi. The grant titled "Surveying Impacts of Community Context on Adaptive Mutational Landscapes" will run from September 1, 2023 to August 31, 2025. The project aims to examine how community context alters species evolution using new techniques in whole-genome analyses. It will bridge the fields of...
This three-year, $321,668 Project Grant from the National Science Foundation's Division of Emerging Frontiers will fund research into the impact of horizontal gene transfer on genetic evolution in bacteria. Awarded to Yale University on February 1, 2022 and set to be completed by January 31, 2025, this grant supports work under the Biological Sciences program (CFDA 47.074). Specifically, the grant will further the biological sciences and understanding of major problems by funding three aims....
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 aims to develop a platform for detecting genetic antibiotic resistance motifs that can predict current and future susceptibility to therapeutics. The project will establish the feasibility of leveraging mutational signatures in bacterial DNA to identify antibiotic resistance status, including the potential for rapid development of multi-drug resistance. This approach...
The National Science Foundation (NSF) awarded a $1,500,000 Project Grant under the Biological Sciences (CFDA 47.074) federal grant program to the University of Alabama at Birmingham (UAB). The grant, titled "Horizontal Gene Transfer at Landscape Scale in Microbial Communities Under Selection for Antimicrobial Resistance," will study the spread of antibiotic resistance genes in microbial communities and how this spread is affected by heavy metal pollution. The research will use a unique...
This three-year National Science Foundation project grant of $799,491 will fund research into the role of horizontal gene transfer in the evolution of antibiotic resistance among bacterial communities. The University of Washington will receive the funding to conduct three related research aims. First, the researchers will propagate communities of Escherichia coli, Salmonella enterica, and Klebsiella pneumoniae bacteria and monitor the evolution of a plasmid-borne gene conferring beta-lactam...
This Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) Federal Grant Program provides $700,000 to The Trustees of Princeton University to investigate how iron-starved bacteria cope with additional stresses, such as nitric oxide. The project aims to increase understanding of bacterial stress responses, with a focus on how iron-starved E. coli and P. aeruginosa species adapt to simultaneous stresses. Utilizing genetic mutants, synthetic biology tools,...
This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $240,000 will fund a 3-year postdoctoral fellowship to research the adaptive response of bacteria to bacteriophage infection and high hydrostatic pressure. The fellow will develop novel fluorescence microscopy techniques to quantify bacterial growth, cell size, and morphology under these environmental stressors using model organisms E. coli, P. aeruginosa, and S. piezotolerans. The project...
This National Science Foundation (NSF) Project Grant, awarded under the Biological Sciences program (CFDA 47.074), provides USD 270,000 in funding for a postdoctoral research fellowship focused on understanding the role of epigenetics in bacterial adaptation. The 3-year fellowship, starting June 1, 2025, will investigate how epigenetic modifications influence the ability of bacteria, such as E. coli, to survive and thrive in changing environments, particularly in response to antimicrobial...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) project grant awarded to Baylor College of Medicine seeks to uncover the specific genes that confer antibiotic resistance in E. coli through a novel approach inspired by statistical physics. The $1,534,925 award spanning Aug 2024 to Jul 2027 will grow E. coli cultures and analyze the mutational ensemble using thermodynamic principles to predict the genes underlying antibiotic resistance. This technique aims to bridge biology and physics, with the potential to identify new drug targets to combat antimicrobial resistance, a significant global health challenge. The project will also develop an educational module on evolutionary theory. No subcontracts are planned under this award.