This $592,188 Project Grant awarded by the National Science Foundation (NSF) under the Engineering program (CFDA 47.041) supports research by the Regents of the University of Michigan to investigate the genetics and biosynthesis of methanobactin, a novel compound produced by bacteria that binds to copper. The project aims to: (1) delineate the function of genes involved in methanobactin production, (2) engineer modified forms of methanobactin with potential for treating copper-related disorders like Wilson's disease, and (3) characterize the regulatory mechanisms controlling methanobactin gene expression. The goal is to enable enhanced methanobactin production to accelerate its clinical development. Additionally, the award includes plans to engage 3rd grade students in hands-on science experiments to promote STEM education. The grant period runs from Sep 1, 2024 to Aug 31, 2027.
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