This three-year National Science Foundation project grant of $799,491 will fund research into the role of horizontal gene transfer in the evolution of antibiotic resistance among bacterial communities. The University of Washington will receive the funding to conduct three related research aims. First, the researchers will propagate communities of Escherichia coli, Salmonella enterica, and Klebsiella pneumoniae bacteria and monitor the evolution of a plasmid-borne gene conferring beta-lactam...
This three-year, $321,668 Project Grant from the National Science Foundation's Division of Emerging Frontiers will fund research into the impact of horizontal gene transfer on genetic evolution in bacteria. Awarded to Yale University on February 1, 2022 and set to be completed by January 31, 2025, this grant supports work under the Biological Sciences program (CFDA 47.074). Specifically, the grant will further the biological sciences and understanding of major problems by funding three aims....
The National Science Foundation (NSF) has awarded a $240,000 Project Grant under the Biological Sciences program (CFDA 47.074) to support a 3-year NSF Postdoctoral Research Fellowship in Biology. The fellowship will fund research and training focused on investigating the process of horizontal gene transfer (HGT) in bacterial communities. The research aims to create a detailed map of how mutations in specific plasmid genes impact a plasmid's ability to spread horizontally between bacteria, as...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) project grant awarded to Baylor College of Medicine seeks to uncover the specific genes that confer antibiotic resistance in E. coli through a novel approach inspired by statistical physics. The $1,534,925 award spanning Aug 2024 to Jul 2027 will grow E. coli cultures and analyze the mutational ensemble using thermodynamic principles to predict the genes underlying antibiotic resistance. This technique aims to bridge...
This three-year, $240,000 project grant from the National Science Foundation's Division of Biological Infrastructure will fund research and outreach activities under the Biological Sciences program (CFDA 47.074). The fellow will conduct a comprehensive survey of bacterial and viral communities in a parasitic plant system to identify horizontal gene transfer events. Microbial interaction networks will be analyzed to understand patterns of gene sharing. Workshops and activities will be developed...
The National Science Foundation (NSF) awarded a $1,500,000 Project Grant under the Biological Sciences (CFDA 47.074) federal grant program to the University of Alabama at Birmingham (UAB). The grant, titled "Horizontal Gene Transfer at Landscape Scale in Microbial Communities Under Selection for Antimicrobial Resistance," will study the spread of antibiotic resistance genes in microbial communities and how this spread is affected by heavy metal pollution. The research will use a unique...
This three-year, $409,923 project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports the development of genomic algorithms and statistical models to study natural gene transfer in transformable bacteria at the University of Wisconsin-Madison. The university will collaborate with partners to generate genome-scale statistical algorithms and computational tools for analyzing molecular and biological drivers of gene transfer events during natural...
This National Science Foundation Project Grant of $410,392 awarded on May 1, 2022 to The Pennsylvania State University supports collaborative research under the Biological Sciences federal grant program (CFDA 47.074) to understand xenobiotic adaptation through investigations of copy number alterations. The three-year project will discover novel aspects of xenobiotic resistance resulting from interactions between mutations and gene amplifications in the context of antibiotic resistance...
The National Institute of General Medical Sciences (NIGMS) awarded a $399,227 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Oregon. The grant will fund research to investigate the mechanisms and consequences of rapid evolution in host-pathogen interactions, with a focus on bacterial pathogens of humans. Specific research areas include studying how evolution of cell surface receptors impacts bacterial colonization and immune...
The National Science Foundation awarded $905,966 under the Engineering (47.041) federal grant program to The Regents of the University of California, Berkeley from June 15, 2022 to May 31, 2027. The award will support the development and validation of a targeted long-read DNA sequencing approach to enable enrichment of antibiotic resistance genes and flanking regions from metagenomic samples. This is intended to facilitate detection of low-abundance antibiotic resistance gene targets and their...