This $1,220,400 Project Grant awarded by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences supports a collaborative research project between investigators in the U.S. and U.K. to better understand the regulatory mechanisms controlling mammalian gene expression. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to define the roles of different DNA regulatory elements and how they work together to precisely control gene expression....
This $320,861 federal Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports research to develop tools for reading expanded genetic alphabets that contain bases beyond the standard A, T, G, and C. The project aims to improve the accuracy of next-generation DNA sequencing for these unnatural base pairs, develop new methods to measure polymerase replication fidelity, and investigate the biocompatibility of unnatural base pairs in...
This $795,135 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at the University of Illinois on protein dynamics under extreme environmental conditions. The four-year award beginning June 1, 2022 will fund three related subprojects investigating how proteins adapt to enable organism survival in stressful environments like heat, pressure and dehydration. The research will study intrinsically disordered protein structure and...
This $660,000 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at the University of Southern California (USC) on how RNA editing regulates synaptic plasticity and behavioral adaptations in the fruit fly Drosophila melanogaster. The project aims to investigate how RNA editing of glutamate-gated chloride and voltage-gated calcium channels impacts neural circuit function, synaptic plasticity, and organismal behaviors....
This three-year, five-hundred twenty-three thousand four-hundred sixty-one dollar project grant from the National Science Foundation's Division of Molecular and Cellular Biosciences will fund research into RNA processing in trypanosome mitochondria. The grant was awarded to Seattle Children's Research Institute on April 1, 2022 and will be completed by March 31, 2025. The project aims to advance understanding of gene expression regulation in trypanosomes, single-celled parasites that alternate...
This Project Grant award of $412,525 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports research focused on understanding the molecular mechanisms that regulate ADAR target recognition and RNA editing. The research, led by the Hundley Lab at Indiana University, aims to define the structural elements and sequences recognized by ADAR RNA binding proteins, and investigate how transcription, cellular...
The National Science Foundation Division of Integrative Organismal Systems awarded a $1.14 million Project Grant to The Marine Biological Laboratory in Woods Hole, Falmouth, Massachusetts. The grant is part of the Biological Sciences program (CFDA 47.074) and will fund research from August 2021 through July 2024 to examine temperature acclimation through RNA editing. As part of the Biological Sciences program's goal to strengthen the Nation's biological research enterprise, this Project Grant...
This five-year $385,645 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research investigating RNA-guided nucleases encoded by transposons across the three domains of life. The grantee, Columbia University, will examine an ancestral family of transposon-encoded enzymes that use guide RNAs to target and cut matching DNA sequences. These enzymes are directly related to CRISPR-Cas9 and CRISPR-Cas12 genome editing tools. The project aims to...
This Project Grant award from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program provides $1,050,000 in funding to The Trustees of Princeton University to deepen the understanding of chemical modifications on ribonucleic acid (RNA) and their role in biological processes. The 3-year project, running from February 2025 to January 2028, will focus on characterizing the RNA modification dihydrouridine (D) and the enzymes that mediate this modification. Key objectives...
This Project Grant award from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences, under the Biological Sciences CFDA program (47.074), will investigate a novel regulatory mechanism called "RNA buffering" that maintains messenger RNA (mRNA) levels despite changes in synthesis and decay rates. The $749,978 project at the University of Utah will explore the protein-protein and protein-RNA interactions involved in this process, which challenges...