This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $1,050,000 in funding to Princeton University to deepen the understanding of chemical modifications on ribonucleic acid (RNA) and their role in biological processes. The 3-year project (2/15/2025 - 1/31/2028) aims to characterize the dihydrouridine (D) RNA modification and the enzymes that install it, as well as investigate the biological function of D modifications in tRNA stability and protein translation. The research will apply chemical biology methods, biochemical studies, high-throughput transcriptomic analyses, and cell biological assays to address major knowledge gaps in RNA modification biology. The project will also provide training opportunities for students and facilitate education and outreach to increase engagement with nucleic acid chemistry and biology.
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