Project Grant 2306188
- This National Science Foundation (NSF) grant under the Biological Sciences program (CFDA 47.074) provides $535,511 to the University of Illinois at Chicago from July 1, 2023 to June 30, 2026. The goal of this collaborative research project is to develop new tools to precisely manipulate the actin cytoskeletal protein within the cell nucleus in order to study its role in regulating gene positioning and expression. The project will create a light-activated probe to track and stabilize nuclear...
- The National Science Foundation awarded a three-year, $533,158 Project Grant to the University of Chicago under the Biological Sciences federal grant program (CFDA 47.074). The grant will fund research to systematically characterize the self-organization and force generation of actin networks and contractile rings within synthetic lipid vesicles. Researchers will reconstitute cytoskeletal protein networks from purified components within giant unilamellar vesicles to define the essential elements...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded $508,806 under the Biological Sciences (CFDA 47.074) federal grant program to the Regents of the University of Michigan for a collaborative research project titled "Mechanics of Reconstituted Self-Organized Contractile Actomyosin Systems." The project aims to advance understanding of cytoskeletal network self-organization and force generation through reconstituting actin networks and contractile...
- This $1,220,400 Project Grant awarded by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences supports a collaborative research project between investigators in the U.S. and U.K. to better understand the regulatory mechanisms controlling mammalian gene expression. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to define the roles of different DNA regulatory elements and how they work together to precisely control gene expression....
- This three-year, $1,031,012 National Science Foundation project grant supports research at the University of Chicago to develop active adaptive materials inspired by cell mechanics. The goal is to elucidate design principles for soft biomolecular materials whose actuation and shape are reprogrammable, similar to how actin cytoskeleton networks control cell shape and locomotion. Researchers will reconstitute cytoskeleton-like composite networks in vitro and optimize molecular engineering...
- This National Science Foundation award provides $1,656,474 to the University of Colorado Boulder through May 2026 to develop mathematical models of mitosis under the Biological Sciences grant program (CFDA 47.074). The university will build on previous work modeling chromosome segregation during cell division to create a new model integrating deformable nuclear envelope dynamics. Researchers aim to identify how forces within the nuclear envelope drive successful chromosome separation during...
- This $900,052 Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences will fund research into the molecular mechanisms governing cytoskeleton-mediated motility and distribution of peroxisomes and mitochondria in plants. The grant supports three years of collaborative research between Michigan State University and its sub-awardee to advance understanding of how these organelles recruit cytoskeletal motor proteins for directional transport along...
- This National Science Foundation (NSF) Division of Molecular and Cellular Biosciences Project Grant, titled "TUNING MICROTUBULE-ACTIN CROSSTALK TO CONTROL MITOTIC FIDELITY", will provide $488,281 in funding to the University of Washington from August 1, 2023 to July 31, 2026. The project aims to describe a biological phenomenon where small changes in microtubule assembly temporarily promote the delivery of molecules that interfere with the mitotic spindle's ability to properly position...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $414,164 Project Grant under the Biological Sciences CFDA program to the University of Illinois at Chicago. This 3-year grant, awarded on August 15, 2023, will support research to study how enzymes in intermediary metabolism interact with and bind to RNA molecules. The project aims to gain a greater understanding of these protein-RNA interactions and their effects on regulating cellular activities,...
- The National Science Foundation Division of Integrative Organismal Systems awarded a $206,320 Project Grant to the Donald Danforth Plant Science Center for the period of May 1, 2022 through April 30, 2023. The grant supports collaborative research to develop an artificial chromosome system in Chlamydomonas based on CENH3 tethering under the Biological Sciences program (CFDA 47.074). The Biological Sciences program aims to promote progress in the biological sciences and strengthen the nation's...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $669,456 Project Grant to the University of Chicago under the Biological Sciences program (CFDA 47.074) for the project "Collaborative Research: Tools 4 Cells: Developing Next Generation Methods for Studying Cytoskeletal Factors in the Cell Nucleus". This 3-year project aims to develop novel tools to precisely perturb and study the role of the cytoskeletal protein actin within the cell nucleus, including a light-activatable stabilizer of nuclear actin filaments and a system to selectively degrade nuclear actin. These tools will enable researchers to investigate how actin is involved in organizing the genome and regulating gene expression, without disrupting its functions in the cytoplasm. The project will leverage high-resolution chromatin conformation capture, ChIP-seq, and PRO-seq to reveal the impact of nuclear actin dynamics on chromatin organization and transcription. The developed tools will be made available to the broader research community to advance understanding of fundamental mechanisms controlling genome structure and gene regulation.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $669.5k | 7/5/23 |