Project Grant 2246561
- This federal Project Grant award, provided by the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program, supports research into the mechanisms that allow telomeres, the ends of chromosomes, to be protected from degradation and fusion that can lead to diseases like cancer. The $999,626 award to The Cleveland Clinic Foundation, commencing on Sep 1, 2025 and concluding on Aug 31, 2028, will investigate the role of the CCQ1 protein in shielding telomeres and...
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award of $1,000,000 to the University of Michigan provides funding from August 1, 2024 to July 31, 2028 to study the molecular mechanism of telomere maintenance in the model organism Caenorhabditis elegans. The research aims to leverage the simplicity of the worm's shelterin protein complex to answer fundamental questions about the structure and function of these proteins in chromosome end protection and...
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $495,594.00 to the University of California, Santa Barbara to conduct research on the mechanisms underlying DNA double-strand break repair through homologous recombination. The objectives of this 5-year project are to 1) define the steps in recombination altered by DNA interstrand crosslinks, 2) explore how the DNA repair regulatory kinase ATR is activated during double-strand break...
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $350,000 to the University of Iowa to support research on the mechanisms involved in the propagation of chromosome fragments in the germline. The 3-year project aims to investigate how DNA breaks that occur during the formation of egg and sperm cells are stabilized and passed on to the next generation. The research will be conducted using the model organism C. elegans and will...
- The National Science Foundation awarded a $749,999 project grant to Texas A&M Agrilife Research from February 2021 through January 2025 under the Biological Sciences program (CFDA 47.074). The grant supports collaborative research on telomerase structure and evolution in photosynthetic eukaryotes. The Biological Sciences program aims to advance biological knowledge and enhance understanding of major problems through basic research. This award will further those goals by investigating...
- This federal Project Grant award, valued at $541,574.00 and awarded on January 15, 2025, is funded by the National Science Foundation (NSF) under the Biological Sciences (CFDA 47.074) Federal Grant Program. The project, titled "COLLABORATIVE RESEARCH: NSF/MCB-BSF: THE EFFECT OF TRANSCRIPTION FACTOR BINDING ON UV LESION ACCUMULATION", aims to determine whether transcription factor binding to DNA makes it more susceptible to damage or impedes DNA repair, leading to increased genomic...
- This federal Project Grant award of $404,792 from the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) to Yale University supports fundamental research to investigate the mechanisms regulating telomere length, protection, and replication. The research project aims to determine how the human POT1 protein coordinates the recruitment of telomerase and the CTC1-STN1-TEN1 complex to telomeres in order to maintain telomere length. Additionally,...
- This Project Grant award from the National Science Foundation (NSF) Integrative Activities program (CFDA 47.083) will provide $400,000.00 to Marshall University Research Corporation to conduct an integrated study on the relationship between telomere biology, flowering time regulation, and plant reproductive fitness. The 5-year project aims to elucidate the functional mechanisms linking telomere length and plant developmental traits, such as the timing of flowering initiation and seed production,...
- This $1,220,400 Project Grant awarded by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences supports a collaborative research project between investigators in the U.S. and U.K. to better understand the regulatory mechanisms controlling mammalian gene expression. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to define the roles of different DNA regulatory elements and how they work together to precisely control gene expression....
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded Kent State University a $546,146 Project Grant to study the structure, accessibility, and extension of telomeric overhangs. The five-year grant, running from February 1, 2025 to January 31, 2030, will utilize single-molecule fluorescence methods, cryo-electron microscopy, and ensemble techniques to investigate how the structure and stability of...
This Project Grant award from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences, under the Biological Sciences program (CFDA 47.074), provides $910,000 over 4 years to Weill Medical College of Cornell University to conduct research on the regulation of DNA repair mechanisms and transcription at telomeres. The research aims to improve understanding of how genetic information is protected at chromosome ends, which is critical for cell and organism health. The project will use the fungus Ustilago maydis as a model system to investigate the cell cycle regulation of abnormal telomere repair pathways, as well as the factors involved in aberrant telomere transcription and its impact on repair. This foundational work is expected to advance scientific knowledge in this area and provide research training opportunities for community college students, thereby having broader societal benefits.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $910.0k | 6/22/23 |