This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award of $1,000,000 to the University of Michigan provides funding from August 1, 2024 to July 31, 2028 to study the molecular mechanism of telomere maintenance in the model organism Caenorhabditis elegans. The research aims to leverage the simplicity of the worm's shelterin protein complex to answer fundamental questions about the structure and function of these proteins in chromosome end protection and replication, with implications for human genome stability, aging, and cancer. The project will generate research tools for the scientific community and create opportunities for high school, undergraduate, and graduate students to develop experimental and critical thinking skills. Additionally, a display at the host institution's natural history museum will increase the visibility of this research within the local community.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.0m | 7/19/24 |