Project Grant 2530370
- This Project Grant award from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences, under the Biological Sciences program (CFDA 47.074), provides $910,000 over 4 years to Weill Medical College of Cornell University to conduct research on the regulation of DNA repair mechanisms and transcription at telomeres. The research aims to improve understanding of how genetic information is protected at chromosome ends, which is critical for cell and organism health. The...
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award of $1,000,000 to the University of Michigan provides funding from August 1, 2024 to July 31, 2028 to study the molecular mechanism of telomere maintenance in the model organism Caenorhabditis elegans. The research aims to leverage the simplicity of the worm's shelterin protein complex to answer fundamental questions about the structure and function of these proteins in chromosome end protection and...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded Kent State University a $546,146 Project Grant to study the structure, accessibility, and extension of telomeric overhangs. The five-year grant, running from February 1, 2025 to January 31, 2030, will utilize single-molecule fluorescence methods, cryo-electron microscopy, and ensemble techniques to investigate how the structure and stability of...
- This federal Project Grant award of $404,792 from the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) to Yale University supports fundamental research to investigate the mechanisms regulating telomere length, protection, and replication. The research project aims to determine how the human POT1 protein coordinates the recruitment of telomerase and the CTC1-STN1-TEN1 complex to telomeres in order to maintain telomere length. Additionally,...
- The National Science Foundation awarded a $749,999 project grant to Texas A&M Agrilife Research from February 2021 through January 2025 under the Biological Sciences program (CFDA 47.074). The grant supports collaborative research on telomerase structure and evolution in photosynthetic eukaryotes. The Biological Sciences program aims to advance biological knowledge and enhance understanding of major problems through basic research. This award will further those goals by investigating...
- This federal Project Grant award, valued at $541,574.00 and awarded on January 15, 2025, is funded by the National Science Foundation (NSF) under the Biological Sciences (CFDA 47.074) Federal Grant Program. The project, titled "COLLABORATIVE RESEARCH: NSF/MCB-BSF: THE EFFECT OF TRANSCRIPTION FACTOR BINDING ON UV LESION ACCUMULATION", aims to determine whether transcription factor binding to DNA makes it more susceptible to damage or impedes DNA repair, leading to increased genomic...
- The Project Grant award of $531,584 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at Western Kentucky University (WKU) to investigate the mechanisms of telomere maintenance and protection. The project aims to define the factors associated with telomeres in the absence of the CST protein complex, which plays a role in telomere replication and protection, and to identify whether...
- This federal Project Grant award of $635,033, provided by the National Cancer Institute (CFDA 93.393 Cancer Cause and Prevention Research program), supports research to understand the genetic basis of a newly recognized cancer-prone syndrome caused by long telomere length. The award was granted to The Johns Hopkins University, a leading federal research contractor, to conduct comprehensive investigations into this genetic mechanism driving cancer development, which is distinct from tumor...
- This $1,449,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to study the fundamental regulation of extrachromosomal DNA (ecDNA) in cancer genomes. The project aims to develop new live-cell chromatin labeling strategies and integrate advanced imaging, synthetic genome engineering, and optical/genetic perturbation to systematically investigate how ecDNA orchestrates massive...
- This federal Project Grant award of $380,070.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project titled "ACTIVE CHROMOSOME MOVEMENT IN MEIOTIC PAIRING" at the University of California, San Francisco (UCSF). The project aims to investigate the cellular mechanism of meiotic pairing, testing hypotheses regarding the role of telomere-led active motion and nuclear...
This federal Project Grant award, provided by the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program, supports research into the mechanisms that allow telomeres, the ends of chromosomes, to be protected from degradation and fusion that can lead to diseases like cancer. The $999,626 award to The Cleveland Clinic Foundation, commencing on Sep 1, 2025 and concluding on Aug 31, 2028, will investigate the role of the CCQ1 protein in shielding telomeres and preventing them from triggering cellular damage responses. This research is expected to yield fundamental new insights applicable to medicine, agriculture, and biotechnology. The project includes community outreach and training activities for undergraduate and high school students to provide research experience and mentorship opportunities.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $999.6k | 8/18/25 |