Project Grant 2341479
- This Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences, under the Biological Sciences program (CFDA 47.074), provides $300,000 to the University of Kansas Center for Research Inc. from February 1, 2023 to January 31, 2025. The award will support research investigating delivery and trafficking of DNA introduced to cells from environmental sources using the genetically tractable organism Caenorhabditis elegans. The project aims to gain new...
- The University of Iowa received a $470,000 National Science Foundation (NSF) Project Grant under the Biological Sciences program (CFDA 47.074) to conduct collaborative research on the effect of transcription factor binding on UV lesion accumulation in the human genome. The research aims to determine whether transcription factor binding enhances the frequency of DNA damage or impairs DNA repair, leading to increased mutation rates in those genomic regions. The project will develop innovative...
- This Project Grant award from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences, under the Biological Sciences program (CFDA 47.074), provides $910,000 over 4 years to Weill Medical College of Cornell University to conduct research on the regulation of DNA repair mechanisms and transcription at telomeres. The research aims to improve understanding of how genetic information is protected at chromosome ends, which is critical for cell and organism health. The...
- This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $240,000 provides funding for a postdoctoral research fellowship from July 1, 2024 to June 30, 2027. The fellowship will support research and training to investigate the rules governing interactions between genomes, environment, and phenotypes, with a focus on understanding how repetitive DNA sequences, particularly a satellite repeat on the X chromosome of Drosophila melanogaster, influence...
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award of $1,000,000 to the University of Michigan provides funding from August 1, 2024 to July 31, 2028 to study the molecular mechanism of telomere maintenance in the model organism Caenorhabditis elegans. The research aims to leverage the simplicity of the worm's shelterin protein complex to answer fundamental questions about the structure and function of these proteins in chromosome end protection and...
- This federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $796,823 to the University of Missouri System to conduct research on the genetic and molecular mechanisms behind meiotic silencing by unpaired DNA. The research aims to better understand how organisms use RNA-based gene silencing systems to identify and suppress the expression of DNA segments lacking a pairing partner, which can indicate the presence of viruses or...
- This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $240,000 provides funding for a postdoctoral research fellowship focused on modeling gene drive with selfish germline stem cells in the Drosophila testis. The key products and services to be delivered through this 3-year project include: Identification of Chinmo protein binding sites on chromatin and Chinmo transcriptional targets in germline stem cells (GSCs) using CUT&RUN and...
- This $999,999 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research at the Donald Danforth Plant Science Center to elucidate the mechanisms initiating de novo chromatin modification cycles in plant cells. Over three years, the award will support experiments using cutting-edge techniques to dissect the molecular triggers establishing heritable DNA methylation patterns and long-term epigenetic silencing of transposable elements and...
- This $750,000 Project Grant award from the National Science Foundation (CFDA 47.074 Biological Sciences) will support collaborative research at the University of Iowa on the evolution and development of fundamental plant reproductive structures called sporangia. The research aims to investigate the molecular genetics of sporangium development in the model fern Ceratopteris, in order to better understand the evolution of sporangia across land plants and fill a knowledge gap about plant...
- This $1,000,000 Project Grant awarded by the National Science Foundation (NSF) Division of Integrative Organismal Systems supports research to examine the genetic and molecular changes that have enabled self-fertility to evolve in two different nematode (worm) species, Caenorhabditis elegans and C. briggsae. The key objectives are to reconstruct the evolutionary steps that allowed specific regulatory proteins (FOG-2 and SHE-1) to emerge from related gene families and become essential...
This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $350,000 to the University of Iowa to support research on the mechanisms involved in the propagation of chromosome fragments in the germline. The 3-year project aims to investigate how DNA breaks that occur during the formation of egg and sperm cells are stabilized and passed on to the next generation. The research will be conducted using the model organism C. elegans and will include educational activities to improve genetics literacy in K-12 students from diverse backgrounds. The project is expected to provide crucial insights into the fundamental biological and genetic processes required for the formation of healthy reproductive cells.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $350.0k | 2/6/24 |