Brandeis University was awarded an $889,060 project grant from the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074) to elucidate the mechanisms that regulate nuclear size in cells. Over three years from August 2022 to July 2025, the researchers will develop a quantitative model proposing that nuclear size is specified by physical factors such as osmotic pressure and membrane tension. They will test this model through theoretical modeling combined with...
This National Science Foundation Project Grant of $673,524 supports research at North Carolina State University to develop a mathematical model of mitosis through the Biological Sciences program (CFDA 47.074). The model will simulate chromosome segregation and nuclear envelope shape change coordination in fission yeast mitosis. Researchers will extend an existing mitosis model to include a deformable elastic nuclear envelope integrating the spindle, chromosomes, and nuclear envelope. They will...
The Regents of the University of California, San Francisco (UCSF) received a $302,799 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) to conduct collaborative research understanding and controlling force generation by the centrin-based contractile system in the ciliate Spirostomum ambiguum. Over a four-year period from June 1, 2023 through May 31, 2027, UCSF researchers will combine experiments and computational modeling to elucidate the...
The Regents of the University of California, San Francisco (UCSF) received a $1,242,532 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences on June 15, 2021 to fund research through May 31, 2025. The grant supports research to define how transcriptionally active euchromatin and repressive heterochromatin domains are maintained over multiple cell generations. Specifically, the University of California, San Francisco will investigate how the...
The National Science Foundation awarded a $538,838 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to The Regents of the University of California, San Francisco for research titled "Collaborative Research: Mapping Protein-Membrane Interactions from Molecules to Cell-Level Dynamics." The research will develop multiscale models to map how individual protein structures and compositions interact with and deform cell membranes at varying scales, from...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 Biomedical Research and Research Training provides $360,100 to The Regents of the University of California, San Francisco (UCSF) to develop a spatiotemporal integrative model of human nuclear pore complex (NPC) assembly. The research aims to computationally reconstruct the assembly process of this large, complex cellular structure over time, leveraging experimental...
This $395,749 Project Grant awarded by the National Science Foundation's (NSF) Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049) will support a multi-tiered research effort by Syracuse University to develop a comprehensive physics framework for understanding how cell nuclei maintain function under extreme mechanical stress. The key products to be delivered under this 4-year award include: Experimental and computational models to predict how cell compression deforms and...
This National Science Foundation award provides $1,656,474 to the University of Colorado Boulder through May 2026 to develop mathematical models of mitosis under the Biological Sciences grant program (CFDA 47.074). The university will build on previous work modeling chromosome segregation during cell division to create a new model integrating deformable nuclear envelope dynamics. Researchers aim to identify how forces within the nuclear envelope drive successful chromosome separation during...
This Project Grant award of $1,117,664 from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program supports research aimed at generating mechanistic understandings of nuclear mechanics and force transmission in human cells. The key objectives are to identify the molecular mechanisms governing the formation, maintenance, and disassembly of linker of nucleoskeleton and cytoskeleton (LINC) protein complexes in response to forces applied on the cell nucleus, measure forces...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $139,341 project grant to the Regents of the University of California, San Francisco (UCSF) under the NSF Biological Sciences program (CFDA 47.074). The 3-year grant, effective August 1, 2023, supports collaborative research to investigate the biomechanical mechanisms underlying wound resilience in the single-celled organism Stentor coeruleus. The research will leverage cell biology, microfluidics, and...